Retinal Nerve Fibre Layer Thickness Increases with Decreasing Spectralis OCT Signal Strength in Normal Eyes

Margaret R. Strampe; Luai Eldweik; Benjamin C. Chaon; Sarah Maki; Tyler Wieland; Celine Satija; Collin McClelland; Michael S. Lee

doi:10.1080/01658107.2019.1653934

Retinal Nerve Fibre Layer Thickness Increases with Decreasing Spectralis OCT Signal Strength in Normal Eyes

Margaret R. Strampe, Luai Eldweik, Benjamin C. Chaon, Sarah Maki, Tyler Wieland, Celine Satija, Collin McClelland, Michael S. Lee

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We sought to determine effect of signal strength on mean retinal nerve fibre layer (RNFL) using Spectralis optical coherence tomography (S-OCT). Thirty normal subjects (18 female, mean 37.9 years, range 24-61) were imaged with S-OCT using variably dense Bangerter foils to alter Q value (1 unit signal strength = 4 units Q). We found a statistically significant (p < 0.01) linear relationship (R = 0.8643) between Q and RNFL (1 unit decrease Q = 0.181 um mean RNFL increase). Unlike previous observations of Cirrus and Stratus OCT, we found RNFL thickness does not decrease with decreasing signal strength in S-OCT.

Original language	English (US)
Pages (from-to)	100-103
Number of pages	4
Journal	Neuro-Ophthalmology
Volume	44
Issue number	2
DOIs	https://doi.org/10.1080/01658107.2019.1653934
State	Published - Mar 3 2020

Keywords

OCT
RNFL
Retinal nerve fiber layer
Spectralis
optical coherence tomography
signal strength

ASJC Scopus subject areas

Ophthalmology
Clinical Neurology

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10.1080/01658107.2019.1653934

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title = "Retinal Nerve Fibre Layer Thickness Increases with Decreasing Spectralis OCT Signal Strength in Normal Eyes",

abstract = "We sought to determine effect of signal strength on mean retinal nerve fibre layer (RNFL) using Spectralis optical coherence tomography (S-OCT). Thirty normal subjects (18 female, mean 37.9 years, range 24-61) were imaged with S-OCT using variably dense Bangerter foils to alter Q value (1 unit signal strength = 4 units Q). We found a statistically significant (p < 0.01) linear relationship (R = 0.8643) between Q and RNFL (1 unit decrease Q = 0.181 um mean RNFL increase). Unlike previous observations of Cirrus and Stratus OCT, we found RNFL thickness does not decrease with decreasing signal strength in S-OCT.",

keywords = "OCT, RNFL, Retinal nerve fiber layer, Spectralis, optical coherence tomography, signal strength",

author = "Strampe, {Margaret R.} and Luai Eldweik and Chaon, {Benjamin C.} and Sarah Maki and Tyler Wieland and Celine Satija and Collin McClelland and Lee, {Michael S.}",

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T1 - Retinal Nerve Fibre Layer Thickness Increases with Decreasing Spectralis OCT Signal Strength in Normal Eyes

AU - Strampe, Margaret R.

AU - Eldweik, Luai

AU - Chaon, Benjamin C.

AU - Maki, Sarah

AU - Wieland, Tyler

AU - Satija, Celine

AU - McClelland, Collin

AU - Lee, Michael S.

PY - 2020/3/3

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KW - RNFL

KW - Retinal nerve fiber layer

KW - Spectralis

KW - optical coherence tomography

KW - signal strength

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Retinal Nerve Fibre Layer Thickness Increases with Decreasing Spectralis OCT Signal Strength in Normal Eyes

Abstract

Keywords

ASJC Scopus subject areas

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