Retinal microenvironment imbalance in dry age-related macular degeneration: A mini-review

Brad P. Barnett, James Handa

Research output: Contribution to journalArticle

Abstract

Background: Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. To prevent what will certainly be a tremendous health and economic burden, effective therapeutics for AMD are urgently needed. To develop these agents in a timely fashion, the molecular pathways that cause disease progression must be elucidated. Objective: To briefly describe the clinical features of AMD, and review the current understanding of the molecular basis of AMD. Methods: A literature review. Results: The discussion will primarily focus on the interplay of oxidative stress and complement dysregulation and the resulting chronic proinflammatory state thought to be central in AMD pathogenesis. Conclusions: Oxidative stress and complement dysregulation play a substantive role in the development of AMD.

Original languageEnglish (US)
Pages (from-to)297-306
Number of pages10
JournalGerontology
Volume59
Issue number4
DOIs
StatePublished - Jun 2013

Fingerprint

Macular Degeneration
Oxidative Stress
Western World
Blindness
Disease Progression
Economics
Health

Keywords

  • Age-related macular degeneration
  • Aging
  • Complement
  • Innate immunity
  • Oxidation-specific epitopes
  • Oxidative stress

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Retinal microenvironment imbalance in dry age-related macular degeneration : A mini-review. / Barnett, Brad P.; Handa, James.

In: Gerontology, Vol. 59, No. 4, 06.2013, p. 297-306.

Research output: Contribution to journalArticle

@article{360e02f5b6b541028f25099810fd3516,
title = "Retinal microenvironment imbalance in dry age-related macular degeneration: A mini-review",
abstract = "Background: Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. To prevent what will certainly be a tremendous health and economic burden, effective therapeutics for AMD are urgently needed. To develop these agents in a timely fashion, the molecular pathways that cause disease progression must be elucidated. Objective: To briefly describe the clinical features of AMD, and review the current understanding of the molecular basis of AMD. Methods: A literature review. Results: The discussion will primarily focus on the interplay of oxidative stress and complement dysregulation and the resulting chronic proinflammatory state thought to be central in AMD pathogenesis. Conclusions: Oxidative stress and complement dysregulation play a substantive role in the development of AMD.",
keywords = "Age-related macular degeneration, Aging, Complement, Innate immunity, Oxidation-specific epitopes, Oxidative stress",
author = "Barnett, {Brad P.} and James Handa",
year = "2013",
month = "6",
doi = "10.1159/000346169",
language = "English (US)",
volume = "59",
pages = "297--306",
journal = "Gerontology",
issn = "0304-324X",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Retinal microenvironment imbalance in dry age-related macular degeneration

T2 - A mini-review

AU - Barnett, Brad P.

AU - Handa, James

PY - 2013/6

Y1 - 2013/6

N2 - Background: Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. To prevent what will certainly be a tremendous health and economic burden, effective therapeutics for AMD are urgently needed. To develop these agents in a timely fashion, the molecular pathways that cause disease progression must be elucidated. Objective: To briefly describe the clinical features of AMD, and review the current understanding of the molecular basis of AMD. Methods: A literature review. Results: The discussion will primarily focus on the interplay of oxidative stress and complement dysregulation and the resulting chronic proinflammatory state thought to be central in AMD pathogenesis. Conclusions: Oxidative stress and complement dysregulation play a substantive role in the development of AMD.

AB - Background: Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. To prevent what will certainly be a tremendous health and economic burden, effective therapeutics for AMD are urgently needed. To develop these agents in a timely fashion, the molecular pathways that cause disease progression must be elucidated. Objective: To briefly describe the clinical features of AMD, and review the current understanding of the molecular basis of AMD. Methods: A literature review. Results: The discussion will primarily focus on the interplay of oxidative stress and complement dysregulation and the resulting chronic proinflammatory state thought to be central in AMD pathogenesis. Conclusions: Oxidative stress and complement dysregulation play a substantive role in the development of AMD.

KW - Age-related macular degeneration

KW - Aging

KW - Complement

KW - Innate immunity

KW - Oxidation-specific epitopes

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=84879606778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879606778&partnerID=8YFLogxK

U2 - 10.1159/000346169

DO - 10.1159/000346169

M3 - Article

C2 - 23406680

AN - SCOPUS:84879606778

VL - 59

SP - 297

EP - 306

JO - Gerontology

JF - Gerontology

SN - 0304-324X

IS - 4

ER -