Retinal microenvironment imbalance in dry age-related macular degeneration: A mini-review

Brad P. Barnett, James T. Handa

Research output: Contribution to journalReview article

Abstract

Background: Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. To prevent what will certainly be a tremendous health and economic burden, effective therapeutics for AMD are urgently needed. To develop these agents in a timely fashion, the molecular pathways that cause disease progression must be elucidated. Objective: To briefly describe the clinical features of AMD, and review the current understanding of the molecular basis of AMD. Methods: A literature review. Results: The discussion will primarily focus on the interplay of oxidative stress and complement dysregulation and the resulting chronic proinflammatory state thought to be central in AMD pathogenesis. Conclusions: Oxidative stress and complement dysregulation play a substantive role in the development of AMD.

Original languageEnglish (US)
Pages (from-to)297-306
Number of pages10
JournalGerontology
Volume59
Issue number4
DOIs
StatePublished - Jun 1 2013

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Keywords

  • Age-related macular degeneration
  • Aging
  • Complement
  • Innate immunity
  • Oxidation-specific epitopes
  • Oxidative stress

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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