TY - JOUR
T1 - Retinal laser photocoagulation
T2 - Effect of rate of energy delivery
AU - Smiddy, William E.
AU - Fine, Stuart L.
AU - Quigley, Harry A.
PY - 1989
Y1 - 1989
N2 - Three monkeys were treated with krypton red laser photocoagulation in a manner simulating treatment of a choroidal neo-vascular membrane. One eye of each monkey was treated by employing immediately the power level needed to produce a lesion judged biomicroscopically to be of sufficient intensity (Method A). The fellow eye was treated by starting with lower power levels and then gradually increasing to the level needed to produce a similar-appearing lesion (Method B). Parameters of spot size and treatment duration were kept constant. Animals were sacrificed three days, eight days, and four months after treatment.Both methods of treatments spared the overlying ganglion cell layer in all fundus locations, but Method A induced cell loss in the inner nuclear layer while Method B spared it. Since reaching the clinical endpoint for Method B required fewer spots at the highest power level, the number of spots at the highest power level is probably the most important factor in determining degree of inner retinal absorption. Since both methods of treatment resulted in satisfactory closure in the choriocapillaries, the histopathologic differences may not be clinically important.
AB - Three monkeys were treated with krypton red laser photocoagulation in a manner simulating treatment of a choroidal neo-vascular membrane. One eye of each monkey was treated by employing immediately the power level needed to produce a lesion judged biomicroscopically to be of sufficient intensity (Method A). The fellow eye was treated by starting with lower power levels and then gradually increasing to the level needed to produce a similar-appearing lesion (Method B). Parameters of spot size and treatment duration were kept constant. Animals were sacrificed three days, eight days, and four months after treatment.Both methods of treatments spared the overlying ganglion cell layer in all fundus locations, but Method A induced cell loss in the inner nuclear layer while Method B spared it. Since reaching the clinical endpoint for Method B required fewer spots at the highest power level, the number of spots at the highest power level is probably the most important factor in determining degree of inner retinal absorption. Since both methods of treatment resulted in satisfactory closure in the choriocapillaries, the histopathologic differences may not be clinically important.
KW - Choroidal neovascular membrane
KW - Krypton red laser photocoagulation
KW - Laser histopathology
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U2 - 10.1097/00006982-198909030-00006
DO - 10.1097/00006982-198909030-00006
M3 - Article
C2 - 2595111
AN - SCOPUS:0024466647
SN - 0275-004X
VL - 9
SP - 193
EP - 198
JO - Retina
JF - Retina
IS - 3
ER -