TY - JOUR
T1 - Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma
AU - Quigley, Harry A.
AU - Dunkelberger, Gregory R.
AU - Green, W. Richard
N1 - Funding Information:
This study was supported in part by Public Health ServiceResearchGrantsEY02120(Dr. Quigley)andEY 01765 (Core Facility Grant, Wilmer Institute), both from the National Eye Institute; and by unrestricted funds from National Glaucoma Research; American Health Assistance Foundation, Washington, D.C.; a Senior Investigator Award from Research to Prevent Blindness, Inc.: the Alcon Research Institute, Ft. Worth, Texas; and the H. Charles Greene Foundation, Inc., Baltimore, Maryland.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1989/5/15
Y1 - 1989/5/15
N2 - We measured the number and size of retinal ganglion cells from six human eyes with glaucoma. In each, the histologic findings were correlated with visual field results. Five agematched normal eyes were studied for comparison. In general, there were fewer remaining large ganglion cells in retinal areas with atrophy. In the perifoveal area, however, no consistent pattern of cell loss by size was found. Our estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells. Throughout the central 30 degrees of the retina, 20% of the normal number of cells were gone in locations with a 5-dB sensitivity loss, and 40% cell loss corresponded to a 10-dB decrease. There were some remaining ganglion cells in areas that had 0-dB sensitivity in the field test.
AB - We measured the number and size of retinal ganglion cells from six human eyes with glaucoma. In each, the histologic findings were correlated with visual field results. Five agematched normal eyes were studied for comparison. In general, there were fewer remaining large ganglion cells in retinal areas with atrophy. In the perifoveal area, however, no consistent pattern of cell loss by size was found. Our estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells. Throughout the central 30 degrees of the retina, 20% of the normal number of cells were gone in locations with a 5-dB sensitivity loss, and 40% cell loss corresponded to a 10-dB decrease. There were some remaining ganglion cells in areas that had 0-dB sensitivity in the field test.
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U2 - 10.1016/0002-9394(89)90488-1
DO - 10.1016/0002-9394(89)90488-1
M3 - Article
C2 - 2712129
AN - SCOPUS:0024402107
SN - 0002-9394
VL - 107
SP - 453
EP - 464
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 5
ER -