Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma

Harry A Quigley, Gregory R. Dunkelberger, W. Richard Green

Research output: Contribution to journalArticle

Abstract

We measured the number and size of retinal ganglion cells from six human eyes with glaucoma. In each, the histologic findings were correlated with visual field results. Five agematched normal eyes were studied for comparison. In general, there were fewer remaining large ganglion cells in retinal areas with atrophy. In the perifoveal area, however, no consistent pattern of cell loss by size was found. Our estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells. Throughout the central 30 degrees of the retina, 20% of the normal number of cells were gone in locations with a 5-dB sensitivity loss, and 40% cell loss corresponded to a 10-dB decrease. There were some remaining ganglion cells in areas that had 0-dB sensitivity in the field test.

Original languageEnglish (US)
Pages (from-to)453-464
Number of pages12
JournalAmerican Journal of Ophthalmology
Volume107
Issue number5
DOIs
StatePublished - May 15 1989

Fingerprint

Visual Field Tests
Retinal Ganglion Cells
Glaucoma
Atrophy
Visual Fields
Ganglia
Cell Size
Retina
Cell Count

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma. / Quigley, Harry A; Dunkelberger, Gregory R.; Green, W. Richard.

In: American Journal of Ophthalmology, Vol. 107, No. 5, 15.05.1989, p. 453-464.

Research output: Contribution to journalArticle

Quigley, Harry A ; Dunkelberger, Gregory R. ; Green, W. Richard. / Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma. In: American Journal of Ophthalmology. 1989 ; Vol. 107, No. 5. pp. 453-464.
@article{205ba63b05b245acb26fb317650472ce,
title = "Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma",
abstract = "We measured the number and size of retinal ganglion cells from six human eyes with glaucoma. In each, the histologic findings were correlated with visual field results. Five agematched normal eyes were studied for comparison. In general, there were fewer remaining large ganglion cells in retinal areas with atrophy. In the perifoveal area, however, no consistent pattern of cell loss by size was found. Our estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells. Throughout the central 30 degrees of the retina, 20{\%} of the normal number of cells were gone in locations with a 5-dB sensitivity loss, and 40{\%} cell loss corresponded to a 10-dB decrease. There were some remaining ganglion cells in areas that had 0-dB sensitivity in the field test.",
author = "Quigley, {Harry A} and Dunkelberger, {Gregory R.} and Green, {W. Richard}",
year = "1989",
month = "5",
day = "15",
doi = "10.1016/0002-9394(89)90488-1",
language = "English (US)",
volume = "107",
pages = "453--464",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "5",

}

TY - JOUR

T1 - Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma

AU - Quigley, Harry A

AU - Dunkelberger, Gregory R.

AU - Green, W. Richard

PY - 1989/5/15

Y1 - 1989/5/15

N2 - We measured the number and size of retinal ganglion cells from six human eyes with glaucoma. In each, the histologic findings were correlated with visual field results. Five agematched normal eyes were studied for comparison. In general, there were fewer remaining large ganglion cells in retinal areas with atrophy. In the perifoveal area, however, no consistent pattern of cell loss by size was found. Our estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells. Throughout the central 30 degrees of the retina, 20% of the normal number of cells were gone in locations with a 5-dB sensitivity loss, and 40% cell loss corresponded to a 10-dB decrease. There were some remaining ganglion cells in areas that had 0-dB sensitivity in the field test.

AB - We measured the number and size of retinal ganglion cells from six human eyes with glaucoma. In each, the histologic findings were correlated with visual field results. Five agematched normal eyes were studied for comparison. In general, there were fewer remaining large ganglion cells in retinal areas with atrophy. In the perifoveal area, however, no consistent pattern of cell loss by size was found. Our estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells. Throughout the central 30 degrees of the retina, 20% of the normal number of cells were gone in locations with a 5-dB sensitivity loss, and 40% cell loss corresponded to a 10-dB decrease. There were some remaining ganglion cells in areas that had 0-dB sensitivity in the field test.

UR - http://www.scopus.com/inward/record.url?scp=0024402107&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024402107&partnerID=8YFLogxK

U2 - 10.1016/0002-9394(89)90488-1

DO - 10.1016/0002-9394(89)90488-1

M3 - Article

C2 - 2712129

AN - SCOPUS:0024402107

VL - 107

SP - 453

EP - 464

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 5

ER -