Retinal arteriolar diameters and elevated blood pressure

The Atherosclerosis Risk in Communities Study

A. Richey Sharrett, Larry D. Hubbard, Lawton S. Cooper, Paul D. Sorlie, Rosemary J. Brothers, F. Javier Nieto, Joan L. Pinsky, Ronald Klein

Research output: Contribution to journalArticle

Abstract

Narrowing and other changes in retinal arterioles may reflect damage due to hypertension, which may predict stroke and other cardiovascular diseases independently of blood pressure level. Newly developed quantitative methods of assessing retinal narrowing are used to determine whether this sign is related only to current blood pressure or whether it also independently reflects the effects of previous blood pressure. Retinal photography was performed at the third examination of Atherosclerosis Risk in Communities (ARIC) Study in 1993-1995, and results are presented for the 9,300 nondiabetic participants aged 50-71 years. Generalized narrowing of smaller arterioles was strongly and monotonically related to current blood pressure in men and women, whether they were taking antihypertensive medications or not, and, independent of current blood pressure, was consistently and monotonically related to blood pressure levels measured 3 and 6 years before the retinal assessment. Arteriovenous nicking was also independently related to both current and previous blood pressures. The patterns of association suggested that these signs reflect both transient and persisting structural effects of elevated blood pressure, in agreement with the scant pathologic literature available. The findings suggest that retinal assessment may be useful for research on the microvascular contributions to clinical cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)263-270
Number of pages8
JournalAmerican Journal of Epidemiology
Volume150
Issue number3
StatePublished - Aug 1 1999
Externally publishedYes

Fingerprint

Atherosclerosis
Blood Pressure
Arterioles
Cardiovascular Diseases
Photography
Antihypertensive Agents
Stroke
Hypertension
Research

Keywords

  • Arterioles
  • Arteriosclerosis
  • Blood pressure
  • Cardiovascular diseases
  • Microcirculation
  • Retinal artery

ASJC Scopus subject areas

  • Epidemiology

Cite this

Sharrett, A. R., Hubbard, L. D., Cooper, L. S., Sorlie, P. D., Brothers, R. J., Nieto, F. J., ... Klein, R. (1999). Retinal arteriolar diameters and elevated blood pressure: The Atherosclerosis Risk in Communities Study. American Journal of Epidemiology, 150(3), 263-270.

Retinal arteriolar diameters and elevated blood pressure : The Atherosclerosis Risk in Communities Study. / Sharrett, A. Richey; Hubbard, Larry D.; Cooper, Lawton S.; Sorlie, Paul D.; Brothers, Rosemary J.; Nieto, F. Javier; Pinsky, Joan L.; Klein, Ronald.

In: American Journal of Epidemiology, Vol. 150, No. 3, 01.08.1999, p. 263-270.

Research output: Contribution to journalArticle

Sharrett, AR, Hubbard, LD, Cooper, LS, Sorlie, PD, Brothers, RJ, Nieto, FJ, Pinsky, JL & Klein, R 1999, 'Retinal arteriolar diameters and elevated blood pressure: The Atherosclerosis Risk in Communities Study', American Journal of Epidemiology, vol. 150, no. 3, pp. 263-270.
Sharrett AR, Hubbard LD, Cooper LS, Sorlie PD, Brothers RJ, Nieto FJ et al. Retinal arteriolar diameters and elevated blood pressure: The Atherosclerosis Risk in Communities Study. American Journal of Epidemiology. 1999 Aug 1;150(3):263-270.
Sharrett, A. Richey ; Hubbard, Larry D. ; Cooper, Lawton S. ; Sorlie, Paul D. ; Brothers, Rosemary J. ; Nieto, F. Javier ; Pinsky, Joan L. ; Klein, Ronald. / Retinal arteriolar diameters and elevated blood pressure : The Atherosclerosis Risk in Communities Study. In: American Journal of Epidemiology. 1999 ; Vol. 150, No. 3. pp. 263-270.
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