TY - JOUR
T1 - Resveratrol, sirtuins, and viruses
AU - Yang, Tao
AU - Li, Shugang
AU - Zhang, Xuming
AU - Pang, Xiaowu
AU - Lin, Qinlu
AU - Cao, Jianzhong
N1 - Publisher Copyright:
© 2015 John Wiley & Sons, Ltd.
PY - 2015/11
Y1 - 2015/11
N2 - Resveratrol is a natural phenolic product found in some plants in response to stress and has been linked to the many health benefits of red wine. Over the past several decades, a great deal of research has identified diverse biological roles associated with resveratrol, including anti-oxidant, anti-proliferation, anti-inflammation, anti-cancer, anti-fungal, and antiviral activities. Such biological activities of resveratrol are likely mediated through multiple cellular targets or pathways, such as sirtuins, a family of NAD+-dependent deacetylases. In this treatise, the literatures focusing on the roles of resveratrol and sirtuins in modulating infections by a broad-spectrum of viruses are reviewed, with an emphasis on its potential antiviral mechanisms. A working model about the effects of resveratrol on virus infection is proposed to stimulate further researches on this exciting topic.
AB - Resveratrol is a natural phenolic product found in some plants in response to stress and has been linked to the many health benefits of red wine. Over the past several decades, a great deal of research has identified diverse biological roles associated with resveratrol, including anti-oxidant, anti-proliferation, anti-inflammation, anti-cancer, anti-fungal, and antiviral activities. Such biological activities of resveratrol are likely mediated through multiple cellular targets or pathways, such as sirtuins, a family of NAD+-dependent deacetylases. In this treatise, the literatures focusing on the roles of resveratrol and sirtuins in modulating infections by a broad-spectrum of viruses are reviewed, with an emphasis on its potential antiviral mechanisms. A working model about the effects of resveratrol on virus infection is proposed to stimulate further researches on this exciting topic.
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U2 - 10.1002/rmv.1858
DO - 10.1002/rmv.1858
M3 - Review article
C2 - 26479742
AN - SCOPUS:84947419941
SN - 1052-9276
VL - 25
SP - 431
EP - 445
JO - Reviews in Medical Virology
JF - Reviews in Medical Virology
IS - 6
ER -