Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates

Julie A. Mattison, Mingyi Wang, Michel Bernier, Jing Zhang, Sung Soo Park, Stuart Maudsley, Steven S. An, Lakshmi Santhanam, Bronwen Martin, Shakeela Faulkner, Christopher Morrell, Joseph A. Baur, Leonid Peshkin, Danuta Sosnowska, Anna Csiszar, Richard L. Herbert, Edward M. Tilmont, Zoltan Ungvari, Kevin J. Pearson, Edward G. LakattaRafael De Cabo

Research output: Contribution to journalArticle

Abstract

Central arterial wall stiffening, driven by a chronic inflammatory milieu, accompanies arterial diseases, the leading cause of cardiovascular (CV) morbidity and mortality in Western society. An increase in central arterial wall stiffening, measured as an increase in aortic pulse wave velocity (PWV), is a major risk factor for clinical CV disease events. However, no specific therapies to reduce PWV are presently available. In rhesus monkeys, a 2 year diet high in fat and sucrose (HFS) increases not only body weight and cholesterol, but also induces prominent central arterial wall stiffening and increases PWV and inflammation. The observed loss of endothelial cell integrity, lipid and macrophage infiltration, and calcification of the arterial wall were driven by genomic and proteomic signatures of oxidative stress and inflammation. Resveratrol prevented the HFS-induced arterial wall inflammation and the accompanying increase in PWV. Dietary resveratrol may hold promise as a therapy to ameliorate increases in PWV.

Original languageEnglish (US)
Pages (from-to)183-190
Number of pages8
JournalCell Metabolism
Volume20
Issue number1
DOIs
StatePublished - Jul 1 2014

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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    Mattison, J. A., Wang, M., Bernier, M., Zhang, J., Park, S. S., Maudsley, S., An, S. S., Santhanam, L., Martin, B., Faulkner, S., Morrell, C., Baur, J. A., Peshkin, L., Sosnowska, D., Csiszar, A., Herbert, R. L., Tilmont, E. M., Ungvari, Z., Pearson, K. J., ... De Cabo, R. (2014). Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates. Cell Metabolism, 20(1), 183-190. https://doi.org/10.1016/j.cmet.2014.04.018