Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates

Julie A. Mattison, Mingyi Wang, Michel Bernier, Jing Zhang, Sung Soo Park, Stuart Maudsley, Steven An, Lakshmi Santhanam, Bronwen Martin, Shakeela Faulkner, Christopher Morrell, Joseph A. Baur, Leonid Peshkin, Danuta Sosnowska, Anna Csiszar, Richard L. Herbert, Edward M. Tilmont, Zoltan Ungvari, Kevin J. Pearson, Edward LakattaRafael De Cabo

Research output: Contribution to journalArticle

Abstract

Central arterial wall stiffening, driven by a chronic inflammatory milieu, accompanies arterial diseases, the leading cause of cardiovascular (CV) morbidity and mortality in Western society. An increase in central arterial wall stiffening, measured as an increase in aortic pulse wave velocity (PWV), is a major risk factor for clinical CV disease events. However, no specific therapies to reduce PWV are presently available. In rhesus monkeys, a 2 year diet high in fat and sucrose (HFS) increases not only body weight and cholesterol, but also induces prominent central arterial wall stiffening and increases PWV and inflammation. The observed loss of endothelial cell integrity, lipid and macrophage infiltration, and calcification of the arterial wall were driven by genomic and proteomic signatures of oxidative stress and inflammation. Resveratrol prevented the HFS-induced arterial wall inflammation and the accompanying increase in PWV. Dietary resveratrol may hold promise as a therapy to ameliorate increases in PWV.

Original languageEnglish (US)
Pages (from-to)183-190
Number of pages8
JournalCell Metabolism
Volume20
Issue number1
DOIs
StatePublished - Jul 1 2014

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Arteritis
Pulse Wave Analysis
High Fat Diet
Primates
Sucrose
Inflammation
Macaca mulatta
Proteomics
Oxidative Stress
Cardiovascular Diseases
Endothelial Cells
Fats
Macrophages
Cholesterol
Body Weight
resveratrol
Morbidity
Lipids
Mortality
Therapeutics

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

Cite this

Mattison, J. A., Wang, M., Bernier, M., Zhang, J., Park, S. S., Maudsley, S., ... De Cabo, R. (2014). Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates. Cell Metabolism, 20(1), 183-190. https://doi.org/10.1016/j.cmet.2014.04.018

Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates. / Mattison, Julie A.; Wang, Mingyi; Bernier, Michel; Zhang, Jing; Park, Sung Soo; Maudsley, Stuart; An, Steven; Santhanam, Lakshmi; Martin, Bronwen; Faulkner, Shakeela; Morrell, Christopher; Baur, Joseph A.; Peshkin, Leonid; Sosnowska, Danuta; Csiszar, Anna; Herbert, Richard L.; Tilmont, Edward M.; Ungvari, Zoltan; Pearson, Kevin J.; Lakatta, Edward; De Cabo, Rafael.

In: Cell Metabolism, Vol. 20, No. 1, 01.07.2014, p. 183-190.

Research output: Contribution to journalArticle

Mattison, JA, Wang, M, Bernier, M, Zhang, J, Park, SS, Maudsley, S, An, S, Santhanam, L, Martin, B, Faulkner, S, Morrell, C, Baur, JA, Peshkin, L, Sosnowska, D, Csiszar, A, Herbert, RL, Tilmont, EM, Ungvari, Z, Pearson, KJ, Lakatta, E & De Cabo, R 2014, 'Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates', Cell Metabolism, vol. 20, no. 1, pp. 183-190. https://doi.org/10.1016/j.cmet.2014.04.018
Mattison, Julie A. ; Wang, Mingyi ; Bernier, Michel ; Zhang, Jing ; Park, Sung Soo ; Maudsley, Stuart ; An, Steven ; Santhanam, Lakshmi ; Martin, Bronwen ; Faulkner, Shakeela ; Morrell, Christopher ; Baur, Joseph A. ; Peshkin, Leonid ; Sosnowska, Danuta ; Csiszar, Anna ; Herbert, Richard L. ; Tilmont, Edward M. ; Ungvari, Zoltan ; Pearson, Kevin J. ; Lakatta, Edward ; De Cabo, Rafael. / Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates. In: Cell Metabolism. 2014 ; Vol. 20, No. 1. pp. 183-190.
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