Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet

Yolanda Jimenez-Gomez, Julie A. Mattison, Kevin J. Pearson, Alejandro Martin-Montalvo, Hector H. Palacios, Alex M. Sossong, Theresa M. Ward, Caitlin M. Younts, Kaitlyn Lewis, Joanne S. Allard, Dan L. Longo, Jonathan P. Belman, Maria M. Malagon, Placido Navas, Mitesh Sanghvi, Ruin Moaddel, Edward M. Tilmont, Richard L. Herbert, Christopher H. Morrell, Josephine M. EganJoseph A. Baur, Luigi Ferrucci, Jonathan S. Bogan, Michel Bernier, Rafael De Cabo

Research output: Contribution to journalArticlepeer-review

Abstract

SUMMARY Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with antiinflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-kB activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS ± resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.

Original languageEnglish (US)
Pages (from-to)533-545
Number of pages13
JournalCell Metabolism
Volume18
Issue number4
DOIs
StatePublished - Oct 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

Fingerprint Dive into the research topics of 'Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet'. Together they form a unique fingerprint.

Cite this