Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet

Yolanda Jimenez-Gomez, Julie A. Mattison, Kevin J. Pearson, Alejandro Martin-Montalvo, Hector H. Palacios, Alex M. Sossong, Theresa M. Ward, Caitlin M. Younts, Kaitlyn Lewis, Joanne S. Allard, Dan L. Longo, Jonathan P. Belman, Maria M. Malagon, Placido Navas, Mitesh Sanghvi, Ruin Moaddel, Edward M. Tilmont, Richard L. Herbert, Christopher H. Morrell, Josephine M. Egan & 5 others Joseph A. Baur, Luigi Ferrucci, Jonathan S. Bogan, Michel Bernier, Rafael De Cabo

Research output: Contribution to journalArticle

Abstract

SUMMARY Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with antiinflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-kB activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS ± resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.

Original languageEnglish (US)
Pages (from-to)533-545
Number of pages13
JournalCell Metabolism
Volume18
Issue number4
DOIs
StatePublished - Oct 1 2013
Externally publishedYes

Fingerprint

High Fat Diet
Macaca mulatta
White Adipose Tissue
Insulin Resistance
Insulin
Adipocytes
Haplorhini
Sirtuin 1
Fats
Diet
Obese Mice
Intra-Abdominal Fat
NF-kappa B
Subcutaneous Fat
Type 2 Diabetes Mellitus
Anti-Inflammatory Agents
Obesity
resveratrol
Inflammation
Glucose

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

Cite this

Jimenez-Gomez, Y., Mattison, J. A., Pearson, K. J., Martin-Montalvo, A., Palacios, H. H., Sossong, A. M., ... De Cabo, R. (2013). Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metabolism, 18(4), 533-545. https://doi.org/10.1016/j.cmet.2013.09.004

Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet. / Jimenez-Gomez, Yolanda; Mattison, Julie A.; Pearson, Kevin J.; Martin-Montalvo, Alejandro; Palacios, Hector H.; Sossong, Alex M.; Ward, Theresa M.; Younts, Caitlin M.; Lewis, Kaitlyn; Allard, Joanne S.; Longo, Dan L.; Belman, Jonathan P.; Malagon, Maria M.; Navas, Placido; Sanghvi, Mitesh; Moaddel, Ruin; Tilmont, Edward M.; Herbert, Richard L.; Morrell, Christopher H.; Egan, Josephine M.; Baur, Joseph A.; Ferrucci, Luigi; Bogan, Jonathan S.; Bernier, Michel; De Cabo, Rafael.

In: Cell Metabolism, Vol. 18, No. 4, 01.10.2013, p. 533-545.

Research output: Contribution to journalArticle

Jimenez-Gomez, Y, Mattison, JA, Pearson, KJ, Martin-Montalvo, A, Palacios, HH, Sossong, AM, Ward, TM, Younts, CM, Lewis, K, Allard, JS, Longo, DL, Belman, JP, Malagon, MM, Navas, P, Sanghvi, M, Moaddel, R, Tilmont, EM, Herbert, RL, Morrell, CH, Egan, JM, Baur, JA, Ferrucci, L, Bogan, JS, Bernier, M & De Cabo, R 2013, 'Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet', Cell Metabolism, vol. 18, no. 4, pp. 533-545. https://doi.org/10.1016/j.cmet.2013.09.004
Jimenez-Gomez, Yolanda ; Mattison, Julie A. ; Pearson, Kevin J. ; Martin-Montalvo, Alejandro ; Palacios, Hector H. ; Sossong, Alex M. ; Ward, Theresa M. ; Younts, Caitlin M. ; Lewis, Kaitlyn ; Allard, Joanne S. ; Longo, Dan L. ; Belman, Jonathan P. ; Malagon, Maria M. ; Navas, Placido ; Sanghvi, Mitesh ; Moaddel, Ruin ; Tilmont, Edward M. ; Herbert, Richard L. ; Morrell, Christopher H. ; Egan, Josephine M. ; Baur, Joseph A. ; Ferrucci, Luigi ; Bogan, Jonathan S. ; Bernier, Michel ; De Cabo, Rafael. / Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet. In: Cell Metabolism. 2013 ; Vol. 18, No. 4. pp. 533-545.
@article{c5f07f2488ba422cac4c8628d15710e5,
title = "Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet",
abstract = "SUMMARY Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with antiinflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-kB activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS ± resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.",
author = "Yolanda Jimenez-Gomez and Mattison, {Julie A.} and Pearson, {Kevin J.} and Alejandro Martin-Montalvo and Palacios, {Hector H.} and Sossong, {Alex M.} and Ward, {Theresa M.} and Younts, {Caitlin M.} and Kaitlyn Lewis and Allard, {Joanne S.} and Longo, {Dan L.} and Belman, {Jonathan P.} and Malagon, {Maria M.} and Placido Navas and Mitesh Sanghvi and Ruin Moaddel and Tilmont, {Edward M.} and Herbert, {Richard L.} and Morrell, {Christopher H.} and Egan, {Josephine M.} and Baur, {Joseph A.} and Luigi Ferrucci and Bogan, {Jonathan S.} and Michel Bernier and {De Cabo}, Rafael",
year = "2013",
month = "10",
day = "1",
doi = "10.1016/j.cmet.2013.09.004",
language = "English (US)",
volume = "18",
pages = "533--545",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "4",

}

TY - JOUR

T1 - Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet

AU - Jimenez-Gomez, Yolanda

AU - Mattison, Julie A.

AU - Pearson, Kevin J.

AU - Martin-Montalvo, Alejandro

AU - Palacios, Hector H.

AU - Sossong, Alex M.

AU - Ward, Theresa M.

AU - Younts, Caitlin M.

AU - Lewis, Kaitlyn

AU - Allard, Joanne S.

AU - Longo, Dan L.

AU - Belman, Jonathan P.

AU - Malagon, Maria M.

AU - Navas, Placido

AU - Sanghvi, Mitesh

AU - Moaddel, Ruin

AU - Tilmont, Edward M.

AU - Herbert, Richard L.

AU - Morrell, Christopher H.

AU - Egan, Josephine M.

AU - Baur, Joseph A.

AU - Ferrucci, Luigi

AU - Bogan, Jonathan S.

AU - Bernier, Michel

AU - De Cabo, Rafael

PY - 2013/10/1

Y1 - 2013/10/1

N2 - SUMMARY Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with antiinflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-kB activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS ± resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.

AB - SUMMARY Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with antiinflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-kB activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS ± resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.

UR - http://www.scopus.com/inward/record.url?scp=84885148256&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885148256&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2013.09.004

DO - 10.1016/j.cmet.2013.09.004

M3 - Article

VL - 18

SP - 533

EP - 545

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 4

ER -