Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet

Yolanda Jimenez-Gomez; Julie A. Mattison; Kevin J. Pearson; Alejandro Martin-Montalvo; Hector H. Palacios; Alex M. Sossong; Theresa M. Ward; Caitlin M. Younts; Kaitlyn Lewis; Joanne S. Allard; Dan L. Longo; Jonathan P. Belman; Maria M. Malagon; Placido Navas; Mitesh Sanghvi; Ruin Moaddel; Edward M. Tilmont; Richard L. Herbert; Christopher H. Morrell; Josephine M. Egan; Joseph A. Baur; Luigi Ferrucci; Jonathan S. Bogan; Michel Bernier; Rafael De Cabo

doi:10.1016/j.cmet.2013.09.004

Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet

Yolanda Jimenez-Gomez, Julie A. Mattison, Kevin J. Pearson, Alejandro Martin-Montalvo, Hector H. Palacios, Alex M. Sossong, Theresa M. Ward, Caitlin M. Younts, Kaitlyn Lewis, Joanne S. Allard, Dan L. Longo, Jonathan P. Belman, Maria M. Malagon, Placido Navas, Mitesh Sanghvi, Ruin Moaddel, Edward M. Tilmont, Richard L. Herbert, Christopher H. Morrell, Josephine M. EganJoseph A. Baur, Luigi Ferrucci, Jonathan S. Bogan, Michel Bernier, Rafael De Cabo

Research output: Contribution to journal › Article › peer-review

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Abstract

SUMMARY Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with antiinflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-kB activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS ± resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.

Original language	English (US)
Pages (from-to)	533-545
Number of pages	13
Journal	Cell Metabolism
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/j.cmet.2013.09.004
State	Published - Oct 1 2013
Externally published	Yes

ASJC Scopus subject areas

Cell Biology
Molecular Biology
Physiology

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Jimenez-Gomez, Y., Mattison, J. A., Pearson, K. J., Martin-Montalvo, A., Palacios, H. H., Sossong, A. M., Ward, T. M., Younts, C. M., Lewis, K., Allard, J. S., Longo, D. L., Belman, J. P., Malagon, M. M., Navas, P., Sanghvi, M., Moaddel, R., Tilmont, E. M., Herbert, R. L., Morrell, C. H., ... De Cabo, R. (2013). Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metabolism, 18(4), 533-545. https://doi.org/10.1016/j.cmet.2013.09.004

Jimenez-Gomez, Y, Mattison, JA, Pearson, KJ, Martin-Montalvo, A, Palacios, HH, Sossong, AM, Ward, TM, Younts, CM, Lewis, K, Allard, JS, Longo, DL, Belman, JP, Malagon, MM, Navas, P, Sanghvi, M, Moaddel, R, Tilmont, EM, Herbert, RL, Morrell, CH, Egan, JM, Baur, JA, Ferrucci, L, Bogan, JS, Bernier, M & De Cabo, R 2013, 'Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet', Cell Metabolism, vol. 18, no. 4, pp. 533-545. https://doi.org/10.1016/j.cmet.2013.09.004

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title = "Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet",

abstract = "SUMMARY Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with antiinflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-kB activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS ± resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.",

author = "Yolanda Jimenez-Gomez and Mattison, {Julie A.} and Pearson, {Kevin J.} and Alejandro Martin-Montalvo and Palacios, {Hector H.} and Sossong, {Alex M.} and Ward, {Theresa M.} and Younts, {Caitlin M.} and Kaitlyn Lewis and Allard, {Joanne S.} and Longo, {Dan L.} and Belman, {Jonathan P.} and Malagon, {Maria M.} and Placido Navas and Mitesh Sanghvi and Ruin Moaddel and Tilmont, {Edward M.} and Herbert, {Richard L.} and Morrell, {Christopher H.} and Egan, {Josephine M.} and Baur, {Joseph A.} and Luigi Ferrucci and Bogan, {Jonathan S.} and Michel Bernier and {De Cabo}, Rafael",

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doi = "10.1016/j.cmet.2013.09.004",

language = "English (US)",

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T1 - Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet

AU - Jimenez-Gomez, Yolanda

AU - Mattison, Julie A.

AU - Pearson, Kevin J.

AU - Martin-Montalvo, Alejandro

AU - Palacios, Hector H.

AU - Sossong, Alex M.

AU - Ward, Theresa M.

AU - Younts, Caitlin M.

AU - Lewis, Kaitlyn

AU - Allard, Joanne S.

AU - Longo, Dan L.

AU - Belman, Jonathan P.

AU - Malagon, Maria M.

AU - Navas, Placido

AU - Sanghvi, Mitesh

AU - Moaddel, Ruin

AU - Tilmont, Edward M.

AU - Herbert, Richard L.

AU - Morrell, Christopher H.

AU - Egan, Josephine M.

AU - Baur, Joseph A.

AU - Ferrucci, Luigi

AU - Bogan, Jonathan S.

AU - Bernier, Michel

AU - De Cabo, Rafael

PY - 2013/10/1

Y1 - 2013/10/1

N2 - SUMMARY Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with antiinflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-kB activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS ± resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.

AB - SUMMARY Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with antiinflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-kB activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS ± resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.

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ER -

Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet

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