TY - JOUR
T1 - Resumption of postpartum sexual activity and menses among HIV-infected women on lifelong antiretroviral treatment compared to HIV-uninfected women in Africa
AU - Dadabhai, Sufia
AU - Makanani, Bonus
AU - Hua, Nan
AU - Kawalazira, Rachel
AU - Taulo, Frank
AU - Gadama, Luis
AU - Taha, Taha E.
N1 - Funding Information:
The main study on which this analysis is based was funded by the National Institute of Child Health and Human Development, National Institutes of Health (grant: R21HD085874 Pregnancy outcomes and infant survival in the era of universal HAART in sub‐Saharan Africa). The authors thank the study participants and their families for being part of this study. The authors are grateful for the study teams in Malawi and the community stakeholders for the excellent collaboration during the conduct of the study.
Publisher Copyright:
© 2020 International Federation of Gynecology and Obstetrics
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Objective: To determine time from delivery to resumption of sexual activity and menses among HIV-infected women on antiretroviral treatment (ART) and HIV-uninfected women. Methods: HIV-infected women on ART and HIV-uninfected women were recruited from five health facilities at delivery and followed prospectively for a maximum of 1 year in Blantyre, Malawi from January 2016 to September 2017. Sociodemographic, clinical, and laboratory data were collected at delivery and 1.5, 3, 6, 9, and 12 months. Descriptive, time to event Kaplan-Meier, and multivariable Cox proportional hazards analyses were conducted. Results: Data on 878 women (460 [52.4%] HIV-uninfected and 418 [47.6%] HIV-infected, P=0.156) who attended at least one follow-up visit were analyzed. Among HIV-uninfected compared to HIV-infected women, respectively, the median number of days to resumption of sexual activity was 180 vs 181; to irregular menses was 82 vs 71; and to regular menses was 245 vs 366. In multivariable models, being married was associated with early resumption of sexual activity (hazard ratio [HR] 1.91, P<0.001), and being HIV-infected and use of an effective method of family planning were associated with later start of regular menses (HR<1.0, P<0.050). Conclusion: Counseling of women on reproductive intentions should start early irrespective of HIV infection or use of ART.
AB - Objective: To determine time from delivery to resumption of sexual activity and menses among HIV-infected women on antiretroviral treatment (ART) and HIV-uninfected women. Methods: HIV-infected women on ART and HIV-uninfected women were recruited from five health facilities at delivery and followed prospectively for a maximum of 1 year in Blantyre, Malawi from January 2016 to September 2017. Sociodemographic, clinical, and laboratory data were collected at delivery and 1.5, 3, 6, 9, and 12 months. Descriptive, time to event Kaplan-Meier, and multivariable Cox proportional hazards analyses were conducted. Results: Data on 878 women (460 [52.4%] HIV-uninfected and 418 [47.6%] HIV-infected, P=0.156) who attended at least one follow-up visit were analyzed. Among HIV-uninfected compared to HIV-infected women, respectively, the median number of days to resumption of sexual activity was 180 vs 181; to irregular menses was 82 vs 71; and to regular menses was 245 vs 366. In multivariable models, being married was associated with early resumption of sexual activity (hazard ratio [HR] 1.91, P<0.001), and being HIV-infected and use of an effective method of family planning were associated with later start of regular menses (HR<1.0, P<0.050). Conclusion: Counseling of women on reproductive intentions should start early irrespective of HIV infection or use of ART.
KW - Africa
KW - Antiretroviral treatment
KW - Effective contraceptive methods
KW - HIV
KW - Malawi
KW - Menses
KW - Reproductive intentions
KW - Resumption of sexual activity
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U2 - 10.1002/ijgo.13113
DO - 10.1002/ijgo.13113
M3 - Article
C2 - 32037538
AN - SCOPUS:85081006994
VL - 149
SP - 211
EP - 218
JO - International Journal of Gynecology and Obstetrics
JF - International Journal of Gynecology and Obstetrics
SN - 0020-7292
IS - 2
ER -