Results from the IRS-IV randomized trial of hyperfractionated radiotherapy in children with rhabdomyosarcoma - A report from the IRSG

Sarah S. Donaldson, Jane Meza, John C. Breneman, William M. Crist, Fran Laurie, Stephen J. Qualman, Moody Wharam

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate the outcome and toxicity of hyperfractionated radiotherapy (HFRT) vs. conventionally fractionated radiotherapy (CFRT) in children with Group III rhabdomyosarcoma (RMS). Methods and Materials: Five hundred fifty-nine children were enrolled into the Intergroup Rhabdomyosarcoma Study IV with Group III RMS. Sixty-nine were ineligible for the analysis because of incorrect group or pathologic findings. Of the 490 remaining, 239 were randomized to HFRT (59.4 Gy in 54 1.1-Gy twice daily fractions) and 251 to CFRT (50.4 Gy in 28 1.8-Gy daily fractions). The age range was

Original languageEnglish (US)
Pages (from-to)718-728
Number of pages11
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume51
Issue number3
DOIs
StatePublished - Nov 1 2001

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Indian spacecraft
Rhabdomyosarcoma
radiation therapy
Radiotherapy
toxicity

Keywords

  • Adolescence
  • Childhood
  • Hyperfractionation
  • IRS-IV
  • Radiotherapy
  • Rhabdomyosarcoma
  • Sarcoma

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Results from the IRS-IV randomized trial of hyperfractionated radiotherapy in children with rhabdomyosarcoma - A report from the IRSG. / Donaldson, Sarah S.; Meza, Jane; Breneman, John C.; Crist, William M.; Laurie, Fran; Qualman, Stephen J.; Wharam, Moody.

In: International Journal of Radiation Oncology, Biology, Physics, Vol. 51, No. 3, 01.11.2001, p. 718-728.

Research output: Contribution to journalArticle

Donaldson, Sarah S. ; Meza, Jane ; Breneman, John C. ; Crist, William M. ; Laurie, Fran ; Qualman, Stephen J. ; Wharam, Moody. / Results from the IRS-IV randomized trial of hyperfractionated radiotherapy in children with rhabdomyosarcoma - A report from the IRSG. In: International Journal of Radiation Oncology, Biology, Physics. 2001 ; Vol. 51, No. 3. pp. 718-728.
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