Restoration of bronchial artery circulation after canine lung allotransplantation

S. S. Siegelman, J. W C Hagstrom, S. K. Koerner, F. J. Veith

Research output: Contribution to journalArticle

Abstract

To evaluate the reestablishment of the bronchial circulation in lung transplantation, the authors studied 10 immunosuppressed dogs up to 14 weeks after left lung allografting. Selective in vivo bronchial arteriograms were performed repetitively via the transfemoral route. In the early postoperative period, no filling of vessels distal to the bronchial anastomosis could be shown. After 12 days, however, continuity of the bronchial arteries across the anastomosis was present, and dye filled ramifications of these vessels were visualized on the secondary and tertiary bronchi. Reconstitution of the bronchial circulation was also confirmed by postmortem studies after injecting the isolated descending thoracic aorta with colored radiopaque material (microfil). The bronchial mucosa at autopsy was examined microscopically. There was no correlation between its viability and bronchial artery regeneration. Although early ischemia of the transplant bronchus may be a factor in the bronchial complications that follow lung transplantation, the present study indicates that this ischemia is not due to failure of bronchial artery regeneration.

Original languageEnglish (US)
Pages (from-to)792-795
Number of pages4
JournalJournal of Thoracic and Cardiovascular Surgery
Volume73
Issue number5
StatePublished - 1977
Externally publishedYes

Fingerprint

Bronchial Arteries
Bronchi
Canidae
Lung Transplantation
Thoracic Aorta
Lung
Regeneration
Ischemia
Silicone Elastomers
Homologous Transplantation
Postoperative Period
Autopsy
Mucous Membrane
Coloring Agents
Dogs
Transplants

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Siegelman, S. S., Hagstrom, J. W. C., Koerner, S. K., & Veith, F. J. (1977). Restoration of bronchial artery circulation after canine lung allotransplantation. Journal of Thoracic and Cardiovascular Surgery, 73(5), 792-795.

Restoration of bronchial artery circulation after canine lung allotransplantation. / Siegelman, S. S.; Hagstrom, J. W C; Koerner, S. K.; Veith, F. J.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 73, No. 5, 1977, p. 792-795.

Research output: Contribution to journalArticle

Siegelman, SS, Hagstrom, JWC, Koerner, SK & Veith, FJ 1977, 'Restoration of bronchial artery circulation after canine lung allotransplantation', Journal of Thoracic and Cardiovascular Surgery, vol. 73, no. 5, pp. 792-795.
Siegelman, S. S. ; Hagstrom, J. W C ; Koerner, S. K. ; Veith, F. J. / Restoration of bronchial artery circulation after canine lung allotransplantation. In: Journal of Thoracic and Cardiovascular Surgery. 1977 ; Vol. 73, No. 5. pp. 792-795.
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