TY - JOUR
T1 - Restoration of β-globin gene expression in mammalian cells by antisense oligonucleotides that modify the aberrant splicing patterns of thalassemic pre-mRNAs
AU - Sierakowska, Halina
AU - Montague, Michael
AU - Agrawal, Sudhir
AU - Kole, Ryszard
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1997
Y1 - 1997
N2 - Antisense 2'-methoxy-oligoribonucleotides targeted to aberrant splice sites in two thalassemic human β-globin pre-mRNAs, IVS2-654 and IVS2-705, expressed in HeLa cells efficiently restore correct splicing with the use of Lipofectamine, Cellfectin and DMRIE-C, in effect reactivating a defective β- globin gene.
AB - Antisense 2'-methoxy-oligoribonucleotides targeted to aberrant splice sites in two thalassemic human β-globin pre-mRNAs, IVS2-654 and IVS2-705, expressed in HeLa cells efficiently restore correct splicing with the use of Lipofectamine, Cellfectin and DMRIE-C, in effect reactivating a defective β- globin gene.
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U2 - 10.1080/07328319708006154
DO - 10.1080/07328319708006154
M3 - Article
AN - SCOPUS:0030832989
SN - 0732-8311
VL - 16
SP - 1173
EP - 1182
JO - Nucleosides and Nucleotides
JF - Nucleosides and Nucleotides
IS - 7-9
ER -