TY - JOUR
T1 - Restless legs syndrome
T2 - A review of clinical and pathophysiologic features
AU - Allen, Richard P.
AU - Earley, Christopher J.
PY - 2001
Y1 - 2001
N2 - Restless legs syndrome (RLS), although long ignored and still much underdiagnosed, disrupts the life and sleep considerably of those who have it. Recent clinical and basic research provides for better definition and pathophysiologic understanding of the disorder. The body of knowledge about this disorder has been expanding rapidly during the past decade and it has altered our concepts of this disorder. This review of RLS covers history, diagnosis, morbidity of sleep disturbance, relation to periodic limb movements in both sleep and waking, secondary causes, severity assessment methods, phenotypes for possible genetic patterns, epidemiology, pathophysiology, and medical treatment considerations. The emphasis on pathophysiology includes consideration of central nervous system localization, neurotransmitter and other systems involved, and the role of iron metabolism. Studies to date support the authors' recently advanced iron-dopamine model of RLS.
AB - Restless legs syndrome (RLS), although long ignored and still much underdiagnosed, disrupts the life and sleep considerably of those who have it. Recent clinical and basic research provides for better definition and pathophysiologic understanding of the disorder. The body of knowledge about this disorder has been expanding rapidly during the past decade and it has altered our concepts of this disorder. This review of RLS covers history, diagnosis, morbidity of sleep disturbance, relation to periodic limb movements in both sleep and waking, secondary causes, severity assessment methods, phenotypes for possible genetic patterns, epidemiology, pathophysiology, and medical treatment considerations. The emphasis on pathophysiology includes consideration of central nervous system localization, neurotransmitter and other systems involved, and the role of iron metabolism. Studies to date support the authors' recently advanced iron-dopamine model of RLS.
KW - Dopamine
KW - Iron
KW - PLMS
KW - RLS
KW - Sleep
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U2 - 10.1097/00004691-200103000-00004
DO - 10.1097/00004691-200103000-00004
M3 - Review article
C2 - 11435804
AN - SCOPUS:0034973123
SN - 0736-0258
VL - 18
SP - 128
EP - 147
JO - Journal of Clinical Neurophysiology
JF - Journal of Clinical Neurophysiology
IS - 2
ER -