TY - JOUR
T1 - Resting state functional connectivity and cognitive task-related activation of the human claustrum
AU - Krimmel, Samuel R.
AU - White, Michael G.
AU - Panicker, Matthew H.
AU - Barrett, Frederick S.
AU - Mathur, Brian N.
AU - Seminowicz, David A.
N1 - Funding Information:
This work was supported by National Institute on Alcohol Abuse and Alcoholism grants K22AA021414 and R01AA024845 (B.N.M.), National Institute of General Medical Sciences grant T32008181 (M.G.W.), National Institute of Neurological Disorders and Stroke grant T32NS063391 (M.G.W.), National Institute on Drug Abuse grant R03DA042336 (F.S.B.), and National Center for Complementary and Integrative Health grant R01AT007176 (D.A.S.); The authors also are grateful for the assistance of Dr. Rao Gullapalli and the Center for Advanced Imaging Research (CAIR).
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Structural and functional analyses of the human claustrum, a poorly understood telencephalic gray matter structure, are hampered by its sheet-like anatomical arrangement. Here, we first describe a functional magnetic resonance imaging (fMRI) method to reveal claustrum signal with no linear relationship with adjacent regions in human subjects. We applied this approach to resting state functional connectivity (RSFC) analysis of the claustrum at high resolution (1.5 mm isotropic voxels) using a 7T dataset (n = 20) and a separate 3T dataset for replication (n = 35). We then assessed claustrum activation during performance of a cognitive task, the multi-source interference task, at 3T (n = 33). Extensive functional connectivity was observed between claustrum and cortical regions associated with cognitive control, including anterior cingulate, prefrontal and parietal cortices. Cognitive task performance was associated with widespread activation and deactivation that overlapped with the cortical areas showing functional connectivity to the claustrum. Furthermore, during high cognitive conflict conditions of the task, the claustrum was significantly activated at the onset of the task, but not during the remainder of the difficult condition. Both of these findings suggest that the human claustrum can be functionally isolated with fMRI, and that it may play a role in cognitive control, and specifically task switching, independent of sensorimotor processing.
AB - Structural and functional analyses of the human claustrum, a poorly understood telencephalic gray matter structure, are hampered by its sheet-like anatomical arrangement. Here, we first describe a functional magnetic resonance imaging (fMRI) method to reveal claustrum signal with no linear relationship with adjacent regions in human subjects. We applied this approach to resting state functional connectivity (RSFC) analysis of the claustrum at high resolution (1.5 mm isotropic voxels) using a 7T dataset (n = 20) and a separate 3T dataset for replication (n = 35). We then assessed claustrum activation during performance of a cognitive task, the multi-source interference task, at 3T (n = 33). Extensive functional connectivity was observed between claustrum and cortical regions associated with cognitive control, including anterior cingulate, prefrontal and parietal cortices. Cognitive task performance was associated with widespread activation and deactivation that overlapped with the cortical areas showing functional connectivity to the claustrum. Furthermore, during high cognitive conflict conditions of the task, the claustrum was significantly activated at the onset of the task, but not during the remainder of the difficult condition. Both of these findings suggest that the human claustrum can be functionally isolated with fMRI, and that it may play a role in cognitive control, and specifically task switching, independent of sensorimotor processing.
KW - Attention
KW - Insula
KW - Putamen
KW - Striatum
KW - Thalamus
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U2 - 10.1016/j.neuroimage.2019.03.075
DO - 10.1016/j.neuroimage.2019.03.075
M3 - Article
C2 - 30954711
AN - SCOPUS:85064116366
SN - 1053-8119
VL - 196
SP - 59
EP - 67
JO - NeuroImage
JF - NeuroImage
ER -