Resting state connectivity of the bed nucleus of the stria terminalis at ultra-high field

Salvatore Torrisi, Katherine O'Connell, Andrew Davis, Richard Reynolds, Nicholas Balderston, Julie L. Fudge, Christian Grillon, Monique Ernst

Research output: Contribution to journalArticle

Abstract

The bed nucleus of the stria terminalis (BNST), a portion of the "extended amygdala," is implicated in the pathophysiology of anxiety and addiction disorders. Its small size and connection to other small regions prevents standard imaging techniques from easily capturing it and its connectivity with confidence. Seed-based resting state functional connectivity is an established method for mapping functional connections across the brain from a region of interest. We, therefore, mapped the BNST resting state network with high spatial resolution using 7 Tesla fMRI, demonstrating the in vivo reproduction of many human BNST connections previously described only in animal research. We identify strong BNST functional connectivity in amygdala, hippocampus and thalamic subregions, caudate, periaqueductal gray, hypothalamus, and cortical areas such as the medial PFC and precuneus. This work, which demonstrates the power of ultra-high field for mapping functional connections in the human, is an important step toward elucidating cortical and subcortical regions and subregions of the BNST network.

Original languageEnglish (US)
Pages (from-to)4076-4088
Number of pages13
JournalHuman Brain Mapping
Volume36
Issue number10
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

Fingerprint

Septal Nuclei
Amygdala
Periaqueductal Gray
Parietal Lobe
Anxiety Disorders
Hypothalamus
Reproduction
Hippocampus
Seeds
Magnetic Resonance Imaging
Brain

Keywords

  • 7 Tesla
  • Bed nucleus of the stria terminalis
  • Resting state

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Torrisi, S., O'Connell, K., Davis, A., Reynolds, R., Balderston, N., Fudge, J. L., ... Ernst, M. (2015). Resting state connectivity of the bed nucleus of the stria terminalis at ultra-high field. Human Brain Mapping, 36(10), 4076-4088. https://doi.org/10.1002/hbm.22899

Resting state connectivity of the bed nucleus of the stria terminalis at ultra-high field. / Torrisi, Salvatore; O'Connell, Katherine; Davis, Andrew; Reynolds, Richard; Balderston, Nicholas; Fudge, Julie L.; Grillon, Christian; Ernst, Monique.

In: Human Brain Mapping, Vol. 36, No. 10, 01.10.2015, p. 4076-4088.

Research output: Contribution to journalArticle

Torrisi, S, O'Connell, K, Davis, A, Reynolds, R, Balderston, N, Fudge, JL, Grillon, C & Ernst, M 2015, 'Resting state connectivity of the bed nucleus of the stria terminalis at ultra-high field', Human Brain Mapping, vol. 36, no. 10, pp. 4076-4088. https://doi.org/10.1002/hbm.22899
Torrisi S, O'Connell K, Davis A, Reynolds R, Balderston N, Fudge JL et al. Resting state connectivity of the bed nucleus of the stria terminalis at ultra-high field. Human Brain Mapping. 2015 Oct 1;36(10):4076-4088. https://doi.org/10.1002/hbm.22899
Torrisi, Salvatore ; O'Connell, Katherine ; Davis, Andrew ; Reynolds, Richard ; Balderston, Nicholas ; Fudge, Julie L. ; Grillon, Christian ; Ernst, Monique. / Resting state connectivity of the bed nucleus of the stria terminalis at ultra-high field. In: Human Brain Mapping. 2015 ; Vol. 36, No. 10. pp. 4076-4088.
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