TY - JOUR
T1 - Resting state connectivity of the bed nucleus of the stria terminalis at ultra-high field
AU - Torrisi, Salvatore
AU - O'Connell, Katherine
AU - Davis, Andrew
AU - Reynolds, Richard
AU - Balderston, Nicholas
AU - Fudge, Julie L.
AU - Grillon, Christian
AU - Ernst, Monique
N1 - Publisher Copyright:
© 2015 Wiley Periodicals, Inc.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - The bed nucleus of the stria terminalis (BNST), a portion of the "extended amygdala," is implicated in the pathophysiology of anxiety and addiction disorders. Its small size and connection to other small regions prevents standard imaging techniques from easily capturing it and its connectivity with confidence. Seed-based resting state functional connectivity is an established method for mapping functional connections across the brain from a region of interest. We, therefore, mapped the BNST resting state network with high spatial resolution using 7 Tesla fMRI, demonstrating the in vivo reproduction of many human BNST connections previously described only in animal research. We identify strong BNST functional connectivity in amygdala, hippocampus and thalamic subregions, caudate, periaqueductal gray, hypothalamus, and cortical areas such as the medial PFC and precuneus. This work, which demonstrates the power of ultra-high field for mapping functional connections in the human, is an important step toward elucidating cortical and subcortical regions and subregions of the BNST network.
AB - The bed nucleus of the stria terminalis (BNST), a portion of the "extended amygdala," is implicated in the pathophysiology of anxiety and addiction disorders. Its small size and connection to other small regions prevents standard imaging techniques from easily capturing it and its connectivity with confidence. Seed-based resting state functional connectivity is an established method for mapping functional connections across the brain from a region of interest. We, therefore, mapped the BNST resting state network with high spatial resolution using 7 Tesla fMRI, demonstrating the in vivo reproduction of many human BNST connections previously described only in animal research. We identify strong BNST functional connectivity in amygdala, hippocampus and thalamic subregions, caudate, periaqueductal gray, hypothalamus, and cortical areas such as the medial PFC and precuneus. This work, which demonstrates the power of ultra-high field for mapping functional connections in the human, is an important step toward elucidating cortical and subcortical regions and subregions of the BNST network.
KW - 7 Tesla
KW - Bed nucleus of the stria terminalis
KW - Resting state
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U2 - 10.1002/hbm.22899
DO - 10.1002/hbm.22899
M3 - Article
C2 - 26178381
AN - SCOPUS:84942233711
SN - 1065-9471
VL - 36
SP - 4076
EP - 4088
JO - Human Brain Mapping
JF - Human Brain Mapping
IS - 10
ER -