TY - JOUR
T1 - Resting metabolic rate in old-old women with and without frailty
T2 - Variability and estimation of energy requirements
AU - Weiss, Carlos O.
AU - Cappola, Anne R.
AU - Varadhan, Ravi
AU - Fried, Linda P.
PY - 2012/9
Y1 - 2012/9
N2 - Objectives To measure resting metabolic rate (RMR) in old-old adults living in the community and examine the association between measured RMR and frailty status and compare it with expected RMR generated by a predictive equation. Design Physiological substudy conducted as a home visit within an observational cohort study. Setting Baltimore City and County, Maryland. Participants Seventy-seven women aged 83 to 93 enrolled in the Women's Health and Aging Study II. Measurements Resting metabolic rate with indirect calorimetry, frailty status, fat-free mass, ambient and body temperature, expected RMR according to the Mifflin-St. Jeor equation. Results Average RMR was 1,119 ± 205 kcal/d (range 595-1,560 kcal/d). Agreement between observed and expected RMR was biased and poor (between-subject coefficient of variation 38.0%, 95% confidence interval = 35.1-40.8). Variability of RMR was greater in frail individuals (heteroscedasticity F-test P =.02). Low and high RMR were associated with being frail (odds ratio 5.4, P =.04) and slower self-selected walking speed (P <.001) after adjustment for covariates. Conclusion Equations to predict RMR that are not validated in old-old adults appear to correlate poorly with measured RMR. RMR is highly variable in old-old women, with deviations from the mean predicting clinical frailty. These exploratory findings suggest a pathway to clinical frailty through high or low RMR.
AB - Objectives To measure resting metabolic rate (RMR) in old-old adults living in the community and examine the association between measured RMR and frailty status and compare it with expected RMR generated by a predictive equation. Design Physiological substudy conducted as a home visit within an observational cohort study. Setting Baltimore City and County, Maryland. Participants Seventy-seven women aged 83 to 93 enrolled in the Women's Health and Aging Study II. Measurements Resting metabolic rate with indirect calorimetry, frailty status, fat-free mass, ambient and body temperature, expected RMR according to the Mifflin-St. Jeor equation. Results Average RMR was 1,119 ± 205 kcal/d (range 595-1,560 kcal/d). Agreement between observed and expected RMR was biased and poor (between-subject coefficient of variation 38.0%, 95% confidence interval = 35.1-40.8). Variability of RMR was greater in frail individuals (heteroscedasticity F-test P =.02). Low and high RMR were associated with being frail (odds ratio 5.4, P =.04) and slower self-selected walking speed (P <.001) after adjustment for covariates. Conclusion Equations to predict RMR that are not validated in old-old adults appear to correlate poorly with measured RMR. RMR is highly variable in old-old women, with deviations from the mean predicting clinical frailty. These exploratory findings suggest a pathway to clinical frailty through high or low RMR.
KW - frailty
KW - older adults
KW - resting metabolic rate
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U2 - 10.1111/j.1532-5415.2012.04101.x
DO - 10.1111/j.1532-5415.2012.04101.x
M3 - Article
C2 - 22985142
AN - SCOPUS:84866357986
SN - 0002-8614
VL - 60
SP - 1695
EP - 1700
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 9
ER -