Responsiveness of the National Eye Institute visual function questionnaire to changes in visual acuity: Findings in patients with subfoveal choroidal neovascularization - SST report no. 1

Päivi H. Miskala; Barbara S Hawkins; Carol M. Mangione; Eric B. Bass; Neil M. Bressler; Li Ming Dong; Marta J. Marsh; Leonora Sensinger; Paul Sternberg; Lindy DuBois; Judy Brower; Julia A. Haller; Ann Eager; Tracey Porter; Nancy Melberg-Holekamp; Julie Binning; Lynda Boyd; Hilel Lewis; Ginny Hendricks; Joyce Conway; Anthony Fattori; Susan C. Rath; William J. Wood; Christine Brown; J. Lynn Cruz; Wanda Heath; Catherine Millett; Cynthia Toth; Malcolm M. Anderson; George A. Williams; Mary Zajechowski; H. Richard McDonald; Marsha Apushkin; Kevan E. Curren; Irina Rozenfeld; Margaret Stolarczuk; Frederick H. Davidorf; Jill Milliron; Jerilyn Perry; Robert L. Bergren; Linda Wilcox; Lawrence J. Singerman; Scott D. Marella; Steven D. Schwartz; Lisa Barnhart; Melissa Chun; John T. Minturn; Shelly Cohen; James C. Folk; Betty Follmer; Connie Fountain; William N. Rosenthal; Barbara Petro; Dalton Thibodeaux; Samuel R. Pesin; James M. Haener; John C. Hoskins; Bruce D. Gilliland

doi:10.1001/archopht.121.4.531

Responsiveness of the National Eye Institute visual function questionnaire to changes in visual acuity: Findings in patients with subfoveal choroidal neovascularization - SST report no. 1

Päivi H. Miskala, Barbara S Hawkins, Carol M. Mangione, Eric B. Bass, Neil M. Bressler, Li Ming Dong, Marta J. Marsh, Leonora Sensinger, Paul Sternberg, Lindy DuBois, Judy Brower, Julia A. Haller, Ann Eager, Tracey Porter, Nancy Melberg-Holekamp, Julie Binning, Lynda Boyd, Hilel Lewis, Ginny Hendricks, Joyce ConwayAnthony Fattori, Susan C. Rath, William J. Wood, Christine Brown, J. Lynn Cruz, Wanda Heath, Catherine Millett, Cynthia Toth, Malcolm M. Anderson, George A. Williams, Mary Zajechowski, H. Richard McDonald, Marsha Apushkin, Kevan E. Curren, Irina Rozenfeld, Margaret Stolarczuk, Frederick H. Davidorf, Jill Milliron, Jerilyn Perry, Robert L. Bergren, Linda Wilcox, Lawrence J. Singerman, Scott D. Marella, Steven D. Schwartz, Lisa Barnhart, Melissa Chun, John T. Minturn, Shelly Cohen, James C. Folk, Betty Follmer, Connie Fountain, William N. Rosenthal, Barbara Petro, Dalton Thibodeaux, Samuel R. Pesin, James M. Haener, John C. Hoskins, Bruce D. Gilliland

School of Medicine

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

Background: The National Eye Institute Visual Function Questionnaire (NEI-VFQ) measures vision-targeted quality of life, but it is unclear whether it is sensitive to changes within individuals over time. Objective: To determine the responsiveness of the NEI-VFQ to "within-individual" changes in visual acuity in patients who had subfoveal choroidal neovascularization in at least one eye secondary to age-related macular degeneration, ocular histoplasmosis syndrome, or idiopathic causes, and who participated in randomized trials of submacular surgery. Methods: Trained telephone interviewers administered the NEI-VFQ as part of annual follow-up data collection for pilot trials and larger clinical trials of submacular surgery. Best-corrected visual acuity was measured by local vision examiners at 12 months after enrollment and, typically, by central "traveling" vision examiners at 24 months after enrollment. Changes in visual acuity and NEI-VFQ scores from 12 to 24 months were analyzed using linear regression methods. Results: Two-hundred eighteen patients had both interviews and visual acuity measurements at 12 and 24 months after enrollment. Changes in the overall NEI-VFQ score and in 9 of the subscales (near activities, dependency, driving, role difficulties, distance activities, mental health, general vision, peripheral vision, and social functioning) were related to changes in visual acuity of the better-seeing eye based on linear regression analysis (P < .05). In our analysis, a 3-line decrease in the visual acuity of the better-seeing eye was associated with 3.6-to 16.2-point decreases in the overall NEI-VFQ score and 9 subscale scores. Conclusions: Most of the NEI-VFQ subscales were responsive to changes in the visual acuity of the better-seeing eye over a 12-month interval in this patient population. Thus, the NEI-VFQ can be used to measure change in vision-targeted quality of life over time to augment clinical measurements of visual acuity.

Original language	English (US)
Pages (from-to)	531-539
Number of pages	9
Journal	Archives of ophthalmology
Volume	121
Issue number	4
DOIs	https://doi.org/10.1001/archopht.121.4.531
State	Published - Apr 1 2003

ASJC Scopus subject areas

Ophthalmology

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10.1001/archopht.121.4.531

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Miskala, P. H., Hawkins, B. S., Mangione, C. M., Bass, E. B., Bressler, N. M., Dong, L. M., Marsh, M. J., Sensinger, L., Sternberg, P., DuBois, L., Brower, J., Haller, J. A., Eager, A., Porter, T., Melberg-Holekamp, N., Binning, J., Boyd, L., Lewis, H., Hendricks, G., ... Gilliland, B. D. (2003). Responsiveness of the National Eye Institute visual function questionnaire to changes in visual acuity: Findings in patients with subfoveal choroidal neovascularization - SST report no. 1. Archives of ophthalmology, 121(4), 531-539. https://doi.org/10.1001/archopht.121.4.531

Responsiveness of the National Eye Institute visual function questionnaire to changes in visual acuity: Findings in patients with subfoveal choroidal neovascularization - SST report no. 1. / Miskala, Päivi H.; Hawkins, Barbara S; Mangione, Carol M. et al.
In: Archives of ophthalmology, Vol. 121, No. 4, 01.04.2003, p. 531-539.

Research output: Contribution to journal › Article › peer-review

Miskala, PH, Hawkins, BS, Mangione, CM, Bass, EB , Bressler, NM, Dong, LM, Marsh, MJ, Sensinger, L, Sternberg, P, DuBois, L, Brower, J, Haller, JA, Eager, A, Porter, T, Melberg-Holekamp, N, Binning, J, Boyd, L, Lewis, H, Hendricks, G, Conway, J, Fattori, A, Rath, SC, Wood, WJ, Brown, C, Cruz, JL, Heath, W, Millett, C, Toth, C, Anderson, MM, Williams, GA, Zajechowski, M, McDonald, HR, Apushkin, M, Curren, KE, Rozenfeld, I, Stolarczuk, M, Davidorf, FH, Milliron, J, Perry, J, Bergren, RL, Wilcox, L, Singerman, LJ, Marella, SD, Schwartz, SD, Barnhart, L, Chun, M, Minturn, JT, Cohen, S, Folk, JC, Follmer, B, Fountain, C, Rosenthal, WN, Petro, B, Thibodeaux, D, Pesin, SR, Haener, JM, Hoskins, JC & Gilliland, BD 2003, 'Responsiveness of the National Eye Institute visual function questionnaire to changes in visual acuity: Findings in patients with subfoveal choroidal neovascularization - SST report no. 1', Archives of ophthalmology, vol. 121, no. 4, pp. 531-539. https://doi.org/10.1001/archopht.121.4.531

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title = "Responsiveness of the National Eye Institute visual function questionnaire to changes in visual acuity: Findings in patients with subfoveal choroidal neovascularization - SST report no. 1",

abstract = "Background: The National Eye Institute Visual Function Questionnaire (NEI-VFQ) measures vision-targeted quality of life, but it is unclear whether it is sensitive to changes within individuals over time. Objective: To determine the responsiveness of the NEI-VFQ to {"}within-individual{"} changes in visual acuity in patients who had subfoveal choroidal neovascularization in at least one eye secondary to age-related macular degeneration, ocular histoplasmosis syndrome, or idiopathic causes, and who participated in randomized trials of submacular surgery. Methods: Trained telephone interviewers administered the NEI-VFQ as part of annual follow-up data collection for pilot trials and larger clinical trials of submacular surgery. Best-corrected visual acuity was measured by local vision examiners at 12 months after enrollment and, typically, by central {"}traveling{"} vision examiners at 24 months after enrollment. Changes in visual acuity and NEI-VFQ scores from 12 to 24 months were analyzed using linear regression methods. Results: Two-hundred eighteen patients had both interviews and visual acuity measurements at 12 and 24 months after enrollment. Changes in the overall NEI-VFQ score and in 9 of the subscales (near activities, dependency, driving, role difficulties, distance activities, mental health, general vision, peripheral vision, and social functioning) were related to changes in visual acuity of the better-seeing eye based on linear regression analysis (P < .05). In our analysis, a 3-line decrease in the visual acuity of the better-seeing eye was associated with 3.6-to 16.2-point decreases in the overall NEI-VFQ score and 9 subscale scores. Conclusions: Most of the NEI-VFQ subscales were responsive to changes in the visual acuity of the better-seeing eye over a 12-month interval in this patient population. Thus, the NEI-VFQ can be used to measure change in vision-targeted quality of life over time to augment clinical measurements of visual acuity.",

author = "Miskala, {P{\"a}ivi H.} and Hawkins, {Barbara S} and Mangione, {Carol M.} and Bass, {Eric B.} and Bressler, {Neil M.} and Dong, {Li Ming} and Marsh, {Marta J.} and Leonora Sensinger and Paul Sternberg and Lindy DuBois and Judy Brower and Haller, {Julia A.} and Ann Eager and Tracey Porter and Nancy Melberg-Holekamp and Julie Binning and Lynda Boyd and Hilel Lewis and Ginny Hendricks and Joyce Conway and Anthony Fattori and Rath, {Susan C.} and Wood, {William J.} and Christine Brown and Cruz, {J. Lynn} and Wanda Heath and Catherine Millett and Cynthia Toth and Anderson, {Malcolm M.} and Williams, {George A.} and Mary Zajechowski and McDonald, {H. Richard} and Marsha Apushkin and Curren, {Kevan E.} and Irina Rozenfeld and Margaret Stolarczuk and Davidorf, {Frederick H.} and Jill Milliron and Jerilyn Perry and Bergren, {Robert L.} and Linda Wilcox and Singerman, {Lawrence J.} and Marella, {Scott D.} and Schwartz, {Steven D.} and Lisa Barnhart and Melissa Chun and Minturn, {John T.} and Shelly Cohen and Folk, {James C.} and Betty Follmer and Connie Fountain and Rosenthal, {William N.} and Barbara Petro and Dalton Thibodeaux and Pesin, {Samuel R.} and Haener, {James M.} and Hoskins, {John C.} and Gilliland, {Bruce D.}",

year = "2003",

month = apr,

day = "1",

doi = "10.1001/archopht.121.4.531",

language = "English (US)",

volume = "121",

pages = "531--539",

journal = "Archives of ophthalmology",

issn = "0003-9950",

publisher = "American Medical Association",

number = "4",

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TY - JOUR

T1 - Responsiveness of the National Eye Institute visual function questionnaire to changes in visual acuity

T2 - Findings in patients with subfoveal choroidal neovascularization - SST report no. 1

AU - Miskala, Päivi H.

AU - Hawkins, Barbara S

AU - Mangione, Carol M.

AU - Bass, Eric B.

AU - Bressler, Neil M.

AU - Dong, Li Ming

AU - Marsh, Marta J.

AU - Sensinger, Leonora

AU - Sternberg, Paul

AU - DuBois, Lindy

AU - Brower, Judy

AU - Haller, Julia A.

AU - Eager, Ann

AU - Porter, Tracey

AU - Melberg-Holekamp, Nancy

AU - Binning, Julie

AU - Boyd, Lynda

AU - Lewis, Hilel

AU - Hendricks, Ginny

AU - Conway, Joyce

AU - Fattori, Anthony

AU - Rath, Susan C.

AU - Wood, William J.

AU - Brown, Christine

AU - Cruz, J. Lynn

AU - Heath, Wanda

AU - Millett, Catherine

AU - Toth, Cynthia

AU - Anderson, Malcolm M.

AU - Williams, George A.

AU - Zajechowski, Mary

AU - McDonald, H. Richard

AU - Apushkin, Marsha

AU - Curren, Kevan E.

AU - Rozenfeld, Irina

AU - Stolarczuk, Margaret

AU - Davidorf, Frederick H.

AU - Milliron, Jill

AU - Perry, Jerilyn

AU - Bergren, Robert L.

AU - Wilcox, Linda

AU - Singerman, Lawrence J.

AU - Marella, Scott D.

AU - Schwartz, Steven D.

AU - Barnhart, Lisa

AU - Chun, Melissa

AU - Minturn, John T.

AU - Cohen, Shelly

AU - Folk, James C.

AU - Follmer, Betty

AU - Fountain, Connie

AU - Rosenthal, William N.

AU - Petro, Barbara

AU - Thibodeaux, Dalton

AU - Pesin, Samuel R.

AU - Haener, James M.

AU - Hoskins, John C.

AU - Gilliland, Bruce D.

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Background: The National Eye Institute Visual Function Questionnaire (NEI-VFQ) measures vision-targeted quality of life, but it is unclear whether it is sensitive to changes within individuals over time. Objective: To determine the responsiveness of the NEI-VFQ to "within-individual" changes in visual acuity in patients who had subfoveal choroidal neovascularization in at least one eye secondary to age-related macular degeneration, ocular histoplasmosis syndrome, or idiopathic causes, and who participated in randomized trials of submacular surgery. Methods: Trained telephone interviewers administered the NEI-VFQ as part of annual follow-up data collection for pilot trials and larger clinical trials of submacular surgery. Best-corrected visual acuity was measured by local vision examiners at 12 months after enrollment and, typically, by central "traveling" vision examiners at 24 months after enrollment. Changes in visual acuity and NEI-VFQ scores from 12 to 24 months were analyzed using linear regression methods. Results: Two-hundred eighteen patients had both interviews and visual acuity measurements at 12 and 24 months after enrollment. Changes in the overall NEI-VFQ score and in 9 of the subscales (near activities, dependency, driving, role difficulties, distance activities, mental health, general vision, peripheral vision, and social functioning) were related to changes in visual acuity of the better-seeing eye based on linear regression analysis (P < .05). In our analysis, a 3-line decrease in the visual acuity of the better-seeing eye was associated with 3.6-to 16.2-point decreases in the overall NEI-VFQ score and 9 subscale scores. Conclusions: Most of the NEI-VFQ subscales were responsive to changes in the visual acuity of the better-seeing eye over a 12-month interval in this patient population. Thus, the NEI-VFQ can be used to measure change in vision-targeted quality of life over time to augment clinical measurements of visual acuity.

AB - Background: The National Eye Institute Visual Function Questionnaire (NEI-VFQ) measures vision-targeted quality of life, but it is unclear whether it is sensitive to changes within individuals over time. Objective: To determine the responsiveness of the NEI-VFQ to "within-individual" changes in visual acuity in patients who had subfoveal choroidal neovascularization in at least one eye secondary to age-related macular degeneration, ocular histoplasmosis syndrome, or idiopathic causes, and who participated in randomized trials of submacular surgery. Methods: Trained telephone interviewers administered the NEI-VFQ as part of annual follow-up data collection for pilot trials and larger clinical trials of submacular surgery. Best-corrected visual acuity was measured by local vision examiners at 12 months after enrollment and, typically, by central "traveling" vision examiners at 24 months after enrollment. Changes in visual acuity and NEI-VFQ scores from 12 to 24 months were analyzed using linear regression methods. Results: Two-hundred eighteen patients had both interviews and visual acuity measurements at 12 and 24 months after enrollment. Changes in the overall NEI-VFQ score and in 9 of the subscales (near activities, dependency, driving, role difficulties, distance activities, mental health, general vision, peripheral vision, and social functioning) were related to changes in visual acuity of the better-seeing eye based on linear regression analysis (P < .05). In our analysis, a 3-line decrease in the visual acuity of the better-seeing eye was associated with 3.6-to 16.2-point decreases in the overall NEI-VFQ score and 9 subscale scores. Conclusions: Most of the NEI-VFQ subscales were responsive to changes in the visual acuity of the better-seeing eye over a 12-month interval in this patient population. Thus, the NEI-VFQ can be used to measure change in vision-targeted quality of life over time to augment clinical measurements of visual acuity.

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Responsiveness of the National Eye Institute visual function questionnaire to changes in visual acuity: Findings in patients with subfoveal choroidal neovascularization - SST report no. 1

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