Responses of the SVZ to hypoxia and hypoxia/ischemia

Ryan J. Felling, H. Van Guider, Michael J. Romanko, Steven W. Levison

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Stroke is a devastating injury caused by interruption of the blood supply to the brain. Each year, about 700,000 people in the United States suffer a stroke incurring healthcare costs of more than $50 billion (Heart Disease and Stroke Statistics - 2003 Update, 2002). While advances in the acute treatment of stroke have improved the survival rates, little success has been realized in decreasing the associated morbidity. Stroke survivors suffer a wide range of neurological deficits depending on the location in the brain where the stroke occurs. These effects include, but are not limited to, paralysis, sensory deficits, memory loss and personality changes. Additionally, hypoxic/ischemic (H/I) injury is the single most important cause of brain damage resulting from complications during birth, leading to permanent neurological deficits. Every year, perinatal H/I afflicts approximately 1-2 per 1000 term births and roughly half of surviving preterm infants. Many of these infants suffer long-term handicaps that include learning disabilities, mental retardation, epilepsy and cerebral palsy (Volpe, 2001).

Original languageEnglish (US)
Title of host publicationMammalian Subventricular Zones
Subtitle of host publicationTheir Roles in Brain Development, Cell Replacement and Disease
PublisherSpringer US
Pages242-259
Number of pages18
ISBN (Electronic)9780387313894
ISBN (Print)0387260676, 9780387260679
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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