Response to Dr Stephen Cooper's 'On the use of metaphor to understand, explain, or rationalize redundant genes in yeast'

Xuewen Pan, Daniel Yuan, Ping Ye, Joel Bader, Jef D. Boeke

Research output: Contribution to journalArticle


Earlier use of a metaphor in explaining genetic redundancy in a news article has triggered a commentary and a competing metaphor by Dr Stephen Cooper, who went on to conclude that genetic redundancies are relatively unimportant for microorganisms. We argue here that the new metaphor is flawed and that genetic redundancies are integral to buffering all organisms against environmental and genetic damage.

Original languageEnglish (US)
Pages (from-to)349-350
Number of pages2
JournalFEMS Yeast Research
Issue number3
StatePublished - May 2008



  • DNA repair
  • DNA replication
  • Genetic interactions
  • Saccharomyces cerevisiae
  • Synthetic lethality

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Infectious Diseases

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