Researchers respond to a comment on a method to measure cellular adhesion utilizing a polymer micro-cantilever. The researchers agree with the authors of the comment that additional work is required after functionalizing the micro-cantilever surface with cellular adhesion receptor proteins to achieve optimal physiological measurements as indicated in the manuscript. They have interpreted the differences observed in cells lines, as evidence reflecting their unique cell properties and their studies confirm widely accepted results. The main point of criticism of author of the Comment is that such measurements may not accurately reflect physiological aspects of cell-cell adhesion. The researchers also reveal that cross linkers have been used to attach cells to cantilevers for cell-cell adhesion measurements along with fact that epithelial cells exhibit greater adhesive strength as compared to mesenchymal cells.
ASJC Scopus subject areas
- Physics and Astronomy (miscellaneous)