Response stratification and survival analysis of hepatocellular carcinoma patients treated with intra-arterial therapy using MR imaging-based arterial enhancement fraction

Susanne Bonekamp, David Bonekamp, Jean Francois H Geschwind, Celia Corona Villalobos, Diane K. Reyes, Timothy M. Pawlik, Ihab R Kamel

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate the feasibility that arterial enhancement fraction (AEF) is associated with response of hepatocellular carcinoma (HCC) following intra-arterial therapy (IAT) and to compare AEF response with currently used tumor response metrics.

Materials and Methods: The AEF, Response Evaluation Criteria in Solid Tumors (RECIST), modified RECIST (mRECIST), and European Association for the Study of the Liver (EASL) of the largest treated index lesion and AEF of the tumor-free hepatic parenchyma was measured on representative axial images in 131 patients (108 male; mean age, 61.9 years). Clinical measures and patient survival were assessed. Statistical analysis included Wilcoxon signed-rank test and the COX proportional hazards model.

Results: After IAT, the mean AEF of the tumor decreased by 22% (66.7-44.8%, P

Conclusion: Evaluating the AEF values based on triphasic MRI is associated with tumor response in patients with unresectable HCC treated with IAT.

Original languageEnglish (US)
Pages (from-to)1103-1111
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Volume40
Issue number5
DOIs
StatePublished - Nov 1 2014

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Survival Analysis
Hepatocellular Carcinoma
Neoplasms
Therapeutics
Nonparametric Statistics
Proportional Hazards Models
Survival
Liver
Response Evaluation Criteria in Solid Tumors

Keywords

  • Arterial enhancement fraction
  • Hepatocellular carcinoma
  • Intra-arterial therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Response stratification and survival analysis of hepatocellular carcinoma patients treated with intra-arterial therapy using MR imaging-based arterial enhancement fraction. / Bonekamp, Susanne; Bonekamp, David; Geschwind, Jean Francois H; Corona Villalobos, Celia; Reyes, Diane K.; Pawlik, Timothy M.; Kamel, Ihab R.

In: Journal of Magnetic Resonance Imaging, Vol. 40, No. 5, 01.11.2014, p. 1103-1111.

Research output: Contribution to journalArticle

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AU - Bonekamp, David

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AU - Corona Villalobos, Celia

AU - Reyes, Diane K.

AU - Pawlik, Timothy M.

AU - Kamel, Ihab R

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AB - Purpose: To investigate the feasibility that arterial enhancement fraction (AEF) is associated with response of hepatocellular carcinoma (HCC) following intra-arterial therapy (IAT) and to compare AEF response with currently used tumor response metrics.Materials and Methods: The AEF, Response Evaluation Criteria in Solid Tumors (RECIST), modified RECIST (mRECIST), and European Association for the Study of the Liver (EASL) of the largest treated index lesion and AEF of the tumor-free hepatic parenchyma was measured on representative axial images in 131 patients (108 male; mean age, 61.9 years). Clinical measures and patient survival were assessed. Statistical analysis included Wilcoxon signed-rank test and the COX proportional hazards model.Results: After IAT, the mean AEF of the tumor decreased by 22% (66.7-44.8%, PConclusion: Evaluating the AEF values based on triphasic MRI is associated with tumor response in patients with unresectable HCC treated with IAT.

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