Response Rates of Patients With Metastatic Melanoma to High-Dose Intravenous Interleukin-2 After Prior Exposure to Alpha-Interferon or Low-Dose Interleukin-2

David M. Weinreich, Steven A. Rosenberg

Research output: Contribution to journalArticle


We evaluated 567 patients with metastatic melanoma who were treated with high-dose intravenous interleukin-2 (IL-2) to determine whether prior treatment with either alpha-interferon or low-dose IL-2 altered the rates of response to subsequent high-dose IL-2. Of the 567 patients treated, 46 patients had received low-dose IL-2 before, and 78 had received alpha-interferon before. The response rate for patients who had received IL-2 before compared with IL-2 naïve patients was 15% versus 21% respectively (p = 0.39). The response rate for patients who had received alpha-interferon before compared with patients who had not was 13% versus 21% (p = 0.084). Therefore, prior low-dose IL-2 therapy does not appear to prevent a subsequent response to high-dose IL-2. There is a trend for patients who received alpha-interferon before to have a lower-response rate to subsequent high-dose IL-2, but the number of patients evaluated in this study is too small to definitively answer this question.

Original languageEnglish (US)
Pages (from-to)185-187
Number of pages3
JournalJournal of Immunotherapy
Issue number2
StatePublished - Jan 1 2002



  • Alphainterferon
  • Interleukin-2
  • Metastatic melanoma
  • Prior immunotherapy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology
  • Cancer Research

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