Response of zonal chondrocytes to extracellular matrix-hydrogels

Nathaniel S. Hwang, Shyni Varghese, H. Janice Lee, Parnduangjai Theprungsirikul, Adam Canver, Blanka Sharma, Jennifer Elisseeff

Research output: Contribution to journalArticle


We investigated the biological response of chondrocytes isolated from different zones of articular cartilage and their cellular behaviors in poly (ethylene glycol)-based (PEG) hydrogels containing exogenous type I collagen, hyaluronic acid (HA), or chondroitin sulfate (CS). The cellular morphology was strongly dependent on the extracellular matrix component of hydrogels. Additionally, the exogenous extracellular microenvironment affected matrix production and cartilage specific gene expression of chondrocytes from different zones. CS-based hydrogels showed the strongest response in terms of gene expression and matrix accumulation for both superficial and deep zone chondrocytes, but HA and type I collagen-based hydrogels demonstrated zonal-dependent cellular responses.

Original languageEnglish (US)
Pages (from-to)4172-4178
Number of pages7
JournalFEBS Letters
Issue number22
StatePublished - Sep 4 2007


  • Articular cartilage
  • Chondrocyte
  • Extracellular matrices
  • Gene expression
  • Hydrogel
  • Zonal organization

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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  • Cite this

    Hwang, N. S., Varghese, S., Lee, H. J., Theprungsirikul, P., Canver, A., Sharma, B., & Elisseeff, J. (2007). Response of zonal chondrocytes to extracellular matrix-hydrogels. FEBS Letters, 581(22), 4172-4178.