Response of plasma beta-endorphin immunoreactivity to d-amphetamine and placebo in schizophrenic patients

S. Charles Schulz, Daniel P. van Kammen, David Pickar, Martin R. Cohen, Dieter Naber

Research output: Contribution to journalArticle


The response of plasma β-endorphin (ir) to infusions of randomly assigned d-amphetamine (20 mg) and placebo was studied in eight schizophrenic patients. Although there was no statistically significant difference between the response to d-amphetamine and placebo, significant increases in plasma β-endorphin (ir) levels were observed following each infusion. Although heterogeneity in β-endorphin (ir) response was observed, individual differences did not relate to clinical variables such as abnormalities on computed tomography or "process-reactive" distinctions. An excessive β-endorphin response to placebo in schizophrenia is discussed.

Original languageEnglish (US)
Pages (from-to)171-178
Number of pages8
JournalPsychiatry Research
Issue number2
StatePublished - 1982
Externally publishedYes



  • d-amphetamine
  • placebo response
  • schizophrenia
  • β-Endorphin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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