Response of human polymorphonuclear leukocytes and monocytes to trichosporon beigelii: Host defense against an emerging opportunistic pathogen

Caron A. Lyman, Kelsey F. Garrett, Philip A. Pizzo, Thomas J. Walsh

Research output: Contribution to journalArticlepeer-review

Abstract

To further understand human host defenses against Trichosporon beigelii, functional responses were investigated of polymorphonuclear leukocytes (PMNL) and elutriated human monocytes (EHM) to this opportunistic fungal pathogen. There was significantly less PMNL phagocytosis (P <.001) and killing (P <.001) of T. beigelii isolates than of Candida albicans. However, levels of superoxide anions generated by PMNL in response to T. beigelii and C. albicans were comparable. Pretreatment of PMNL with granulocyte colony-stimulating factor or interferon-v (IFN-’)I) did not significantly enhance fungicidal activity. Killing of T. beigelii by EHM also was significantly impaired comparedwith killing of C. albicans (P <.001). However, pretreatment of EHM with macrophage colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, or IFN-ã all resulted in enhanced fungicidal activity. Thus, phagocytosis and killing of T. beigelii by PMNL andEHM are significantly less efficient than that of C. albicans. However, monocytes may be more important in the control of Trichosporon species than previously shown.

Original languageEnglish (US)
Pages (from-to)1557-1565
Number of pages9
JournalJournal of Infectious Diseases
Volume170
Issue number6
DOIs
StatePublished - Dec 1994

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Response of human polymorphonuclear leukocytes and monocytes to trichosporon beigelii: Host defense against an emerging opportunistic pathogen'. Together they form a unique fingerprint.

Cite this