Response of erythroid Day 3 burst-forming units to endotoxin and erythropoietin

M. J. Koury, T. A. Kost, W. D. Hankins, S. B. Krantz

Research output: Contribution to journalArticlepeer-review

Abstract

When the marrow and spleen cells of plethoric mice are cultured with 1.0 unit/ml of limulus-lysate-absorbed Ep, the predominant erythroid progenitor cell assayed is the Day 3 BFU-E. Erythropoiesis by these cells can be studied by enumeration of bursts at 3 days or by 24-hr 59Fe incorporation into heme. Endotoxin markedly increased the number of Day 3 BFU-E in the spleens of these mice and decreased the number in the marrow, but it had little effect on erythropoietic maturation. In contrast, Ep produced differentiation of the erythroid progenitor cells resulting in increased splenic CFU-E and a decline in the more primitive erythroid precursor cells.

Original languageEnglish (US)
Pages (from-to)275-280
Number of pages6
JournalExperimental Biology and Medicine
Volume162
Issue number2
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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