Response of Bitot's spots in preschool children to vitamin A treatment

Richard David Semba, S. Wirasasmita, G. Natadisastra, Muhilal, Alfred Sommer

Research output: Contribution to journalArticle

Abstract

In a double-masked, placebo-controlled, clinical trial in Indonesia, 88 preschool children between the ages of 36 and 72 months with Bitot's spots were randomly assigned to 200,000 IU of oral vitamin A or placebo and followed up for five weeks. Baseline and follow-up serum vitamin A levels were obtained. Of the 45 children receiving vitamin A, 33 (73.3%) showed complete cure and disappearance of Bitot's spots, six (13.3%) had disappearance of some but not all Bitot's spots, and six (13.3%) were unresponsive to treatment. The nonresponsive children were older, all male, and had higher initial mean serum vitamin A levels, 23.0 μg/dl, compared to 15.9 μg/dl in the cured group (P = .017). These data suggest that normal vitamin A status may be found in approximately 13% of children with Bitot's spots before vitamin A intervention and that one fourth of those who had Bitot's spots originally will not be cured of all Bitot's spots after intervention. These are important factors to consider when using Bitot's spots in prevalence surveys as a clinical sign of vitamin A deficiency.

Original languageEnglish (US)
Pages (from-to)416-420
Number of pages5
JournalAmerican Journal of Ophthalmology
Volume110
Issue number4
StatePublished - 1990

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Preschool Children
Vitamin A
Therapeutics
Placebos
Vitamin A Deficiency
Indonesia
Controlled Clinical Trials
Serum

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Response of Bitot's spots in preschool children to vitamin A treatment. / Semba, Richard David; Wirasasmita, S.; Natadisastra, G.; Muhilal, ; Sommer, Alfred.

In: American Journal of Ophthalmology, Vol. 110, No. 4, 1990, p. 416-420.

Research output: Contribution to journalArticle

Semba, RD, Wirasasmita, S, Natadisastra, G, Muhilal, & Sommer, A 1990, 'Response of Bitot's spots in preschool children to vitamin A treatment', American Journal of Ophthalmology, vol. 110, no. 4, pp. 416-420.
Semba, Richard David ; Wirasasmita, S. ; Natadisastra, G. ; Muhilal, ; Sommer, Alfred. / Response of Bitot's spots in preschool children to vitamin A treatment. In: American Journal of Ophthalmology. 1990 ; Vol. 110, No. 4. pp. 416-420.
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