The EMT6 murine solid tumor was employed to examine the combined effect of gamma irradiation and chemotherapy. A dose of cyclophosphamide, actinomycin D, Carmustine (BCNU), and bleomycin A2, selected to yield a 10% survival fraction when given singly, was administered 2 hours before single graded doses of whole body irradiation and the results compared to a radiation only dose response curve. Bleomycin A2 and BCNU modified the shoulder region of the curve. Actinomycin D was less than additive in the hypoxic region of the curve, while cyclophosphamide was simply additive throughout the curve, suggesting that it killed both well oxygenated and poorly oxygenated tumor cells in similar proportions.
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging