Response Inhibition Deficits and Altered Motor Network Connectivity in the Chronic Phase of Pediatric Traumatic Brain Injury

Jaclyn A. Stephens, Cynthia F Salorio, Jerald P. Gomes, Mary Beth Nebel, Stewart H Mostofsky, Stacy Jennifer M Suskauer

Research output: Contribution to journalArticle

Abstract

Poor response inhibition is a hallmark of pediatric traumatic brain injury (TBI). We assessed motor response inhibition by measuring commission error rates on Simple (minimized cognitive demands) and Motivation (monetary reward) Go/No-Go tasks, comparing 17 children with chronic TBI (>1 year post-injury) and 14 matched, uninjured peers. Using resting state functional magnetic resonance imaging (fMRI), we examined between-group differences in whole-brain intrinsic connectivity of the motor network as derived from the averaged time course of bilateral primary motor cortex seeds, to identify regions of interest (ROIs) for brain-behavior correlations. Independent sample t tests compared Go/No-Go performance and connectivity at the ROI level. Pearson correlations examined relationships between intrinsic connectivity at the ROI level and Go/No-Go performance. Adolescents with TBI showed poorer performance on Simple and Motivation Go/No-Go tasks compared with controls. In whole-brain contrasts, adolescents with TBI showed significantly reduced functional connectivity between the motor network and voxels within the left caudate. Furthermore, in ROI analyses, the group with TBI had significantly lower connectivity between the motor network and left caudate and numerically lower connectivity between the motor network and right caudate. In adolescents with TBI, lower motor network to left caudate connectivity correlated with poorer Simple task performance; lower motor network to right caudate connectivity correlated with poorer Simple and Motivation task performance. No significant brain-behavior relationships existed among controls. These results are consistent with previous pediatric TBI literature and suggest that disrupted intrinsic connectivity of a corticostriatal motor network may contribute to response inhibition deficits.

Original languageEnglish (US)
Pages (from-to)3117-3123
Number of pages7
JournalJournal of Neurotrauma
Volume34
Issue number22
DOIs
StatePublished - Nov 15 2017

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Pediatrics
Motivation
Brain
Task Performance and Analysis
Chronic Brain Injury
Public Opinion
Motor Cortex
Inhibition (Psychology)
Traumatic Brain Injury
Reward
Seeds
Magnetic Resonance Imaging
Wounds and Injuries

Keywords

  • functional connectivity
  • motor network
  • pediatric TBI
  • response inhibition

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Response Inhibition Deficits and Altered Motor Network Connectivity in the Chronic Phase of Pediatric Traumatic Brain Injury. / Stephens, Jaclyn A.; Salorio, Cynthia F; Gomes, Jerald P.; Nebel, Mary Beth; Mostofsky, Stewart H; Suskauer, Stacy Jennifer M.

In: Journal of Neurotrauma, Vol. 34, No. 22, 15.11.2017, p. 3117-3123.

Research output: Contribution to journalArticle

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