Response inhibition among early adolescents prenatally exposed to tobacco: An fMRI study

David S. Bennett; Feroze B. Mohamed; Dennis P. Carmody; Margaret Bendersky; Sunil Patel; Maryam Khorrami; Scott H. Faro; Michael Lewis

doi:10.1016/j.ntt.2009.03.003

Response inhibition among early adolescents prenatally exposed to tobacco: An fMRI study

David S. Bennett, Feroze B. Mohamed, Dennis P. Carmody, Margaret Bendersky, Sunil Patel, Maryam Khorrami, Scott H. Faro, Michael Lewis

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Children prenatally exposed to tobacco have been found to exhibit increased rates of behavior problems related to response inhibition deficits. The present study compared the brain function of tobacco-exposed (n = 7) and unexposed (n = 11) 12-year-olds during a Go/No-Go response inhibition task using an event-related functional MRI (fMRI) design. Prenatal alcohol exposure, neonatal medical problems, environmental risk, IQ, current environmental smoke exposure, and handedness were statistically controlled. Tobacco-exposed children showed greater activation in a relatively large and diverse set of regions, including left frontal, right occipital, and bilateral temporal and parietal regions. In contrast, unexposed but not exposed children showed activation in the cerebellum, which prior research has indicated is important for attention and motor preparation. The diversity of regions showing greater activation among tobacco-exposed children suggests that their brain function is characterized by an inefficient recruitment of regions required for response inhibition.

Original language	English (US)
Pages (from-to)	283-290
Number of pages	8
Journal	Neurotoxicology and Teratology
Volume	31
Issue number	5
DOIs	https://doi.org/10.1016/j.ntt.2009.03.003
State	Published - Sep 2009
Externally published	Yes

Keywords

Cocaine
Executive functioning
Functional magnetic resonance imaging
Prenatal exposure
Response inhibition

ASJC Scopus subject areas

Toxicology
Developmental Neuroscience
Cellular and Molecular Neuroscience

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10.1016/j.ntt.2009.03.003

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@article{a13f8a7023e546b3a605c383e3e0ad0b,

title = "Response inhibition among early adolescents prenatally exposed to tobacco: An fMRI study",

abstract = "Children prenatally exposed to tobacco have been found to exhibit increased rates of behavior problems related to response inhibition deficits. The present study compared the brain function of tobacco-exposed (n = 7) and unexposed (n = 11) 12-year-olds during a Go/No-Go response inhibition task using an event-related functional MRI (fMRI) design. Prenatal alcohol exposure, neonatal medical problems, environmental risk, IQ, current environmental smoke exposure, and handedness were statistically controlled. Tobacco-exposed children showed greater activation in a relatively large and diverse set of regions, including left frontal, right occipital, and bilateral temporal and parietal regions. In contrast, unexposed but not exposed children showed activation in the cerebellum, which prior research has indicated is important for attention and motor preparation. The diversity of regions showing greater activation among tobacco-exposed children suggests that their brain function is characterized by an inefficient recruitment of regions required for response inhibition.",

keywords = "Cocaine, Executive functioning, Functional magnetic resonance imaging, Prenatal exposure, Response inhibition",

author = "Bennett, {David S.} and Mohamed, {Feroze B.} and Carmody, {Dennis P.} and Margaret Bendersky and Sunil Patel and Maryam Khorrami and Faro, {Scott H.} and Michael Lewis",

note = "Funding Information: Portions of this study were presented on June 13, 2006, at the Organization of Human Brain Mapping, Florence, Italy. This study was supported by grant #4100011451 from the Pennsylvania Department of Health (the Department specifically disclaims responsibility for any analyses, interpretations or conclusions) to the first author and by grant DA07109 from the National Institute on Drug Abuse to the last author. The sponsor agencies had no involvement in the study design; collection, analysis, and interpretation of data; writing of this report; or in the decision to submit this report for publication. The authors greatly appreciate the assistance of Sara Ragland in data collection and Monica Martinez in data processing. ",

year = "2009",

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doi = "10.1016/j.ntt.2009.03.003",

language = "English (US)",

volume = "31",

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AU - Bennett, David S.

AU - Mohamed, Feroze B.

AU - Carmody, Dennis P.

AU - Bendersky, Margaret

AU - Patel, Sunil

AU - Khorrami, Maryam

AU - Faro, Scott H.

AU - Lewis, Michael

N1 - Funding Information: Portions of this study were presented on June 13, 2006, at the Organization of Human Brain Mapping, Florence, Italy. This study was supported by grant #4100011451 from the Pennsylvania Department of Health (the Department specifically disclaims responsibility for any analyses, interpretations or conclusions) to the first author and by grant DA07109 from the National Institute on Drug Abuse to the last author. The sponsor agencies had no involvement in the study design; collection, analysis, and interpretation of data; writing of this report; or in the decision to submit this report for publication. The authors greatly appreciate the assistance of Sara Ragland in data collection and Monica Martinez in data processing.

PY - 2009/9

Y1 - 2009/9

N2 - Children prenatally exposed to tobacco have been found to exhibit increased rates of behavior problems related to response inhibition deficits. The present study compared the brain function of tobacco-exposed (n = 7) and unexposed (n = 11) 12-year-olds during a Go/No-Go response inhibition task using an event-related functional MRI (fMRI) design. Prenatal alcohol exposure, neonatal medical problems, environmental risk, IQ, current environmental smoke exposure, and handedness were statistically controlled. Tobacco-exposed children showed greater activation in a relatively large and diverse set of regions, including left frontal, right occipital, and bilateral temporal and parietal regions. In contrast, unexposed but not exposed children showed activation in the cerebellum, which prior research has indicated is important for attention and motor preparation. The diversity of regions showing greater activation among tobacco-exposed children suggests that their brain function is characterized by an inefficient recruitment of regions required for response inhibition.

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KW - Response inhibition

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Response inhibition among early adolescents prenatally exposed to tobacco: An fMRI study

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Keywords

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