TY - JOUR
T1 - Respiratory syncytial virus vaccines
AU - Karron, Ruth A.
AU - Ambrosino, Donna M.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1998
Y1 - 1998
N2 - Progress in RSV vaccine development has been rapid over the last few years. The availability of recombinant technology will allow determination of the genetic basis for attenuation of biologically derived vaccines, as well as the development of new vaccines containing novel combinations of attenuating mutations. This may hasten the identification of live viral vaccine candidates for phase III trials. Additionally, the RSV PFP-2 subunit vaccine is being considered for further phase II studies. Distinct target populations such as infants, pregnant women, the elderly, immunocompromised patients, and children with chronic lung disease may require the use of different vaccines, or combinations of vaccines. It is hoped that the recent advances described here will lead to the development of effective vaccines against this important respiratory pathogen.
AB - Progress in RSV vaccine development has been rapid over the last few years. The availability of recombinant technology will allow determination of the genetic basis for attenuation of biologically derived vaccines, as well as the development of new vaccines containing novel combinations of attenuating mutations. This may hasten the identification of live viral vaccine candidates for phase III trials. Additionally, the RSV PFP-2 subunit vaccine is being considered for further phase II studies. Distinct target populations such as infants, pregnant women, the elderly, immunocompromised patients, and children with chronic lung disease may require the use of different vaccines, or combinations of vaccines. It is hoped that the recent advances described here will lead to the development of effective vaccines against this important respiratory pathogen.
UR - http://www.scopus.com/inward/record.url?scp=0031765470&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031765470&partnerID=8YFLogxK
U2 - 10.1097/00006454-199810000-00014
DO - 10.1097/00006454-199810000-00014
M3 - Short survey
C2 - 9802636
AN - SCOPUS:0031765470
VL - 17
SP - 919
EP - 920
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
SN - 0891-3668
IS - 10
ER -