Respiratory muscle weakness in peripheral neuropathies

Ahmet Z. Burakgazi, Ahmet Höke

Research output: Contribution to journalReview articlepeer-review

Abstract

Common peripheral neuropathies do not usually cause diaphragmatic weakness and subsequent respiratory compromise. However, respiratory involvement is relatively common in Guillain-Barré syndrome (GBS). Experience in GBS has led to a standardized approach to manage respiratory problems in peripheral neuropathies. Diaphragmatic weakness is not common in chronic inflammatory demyelinating polyneuropathy and extremely rare in multifocal motor neuropathy. The linkage has been described between certain subtypes of Charcot-Marie-Tooth (CMT) disease such as CMT2C and CMT4B1 and diaphragmatic weakness. A correlation usually has not been found between electrophysiologic findings and clinical respiratory signs or spirometric abnormalities in peripheral neuropathies except in amplitudes of evoked phrenic nerve responses. Careful and frequent assessment of respiratory function by a qualified team of healthcare professionals and physicians is essential. Criteria established for mechanical ventilation in GBS cases may be applied to other peripheral neuropathies with respiratory compromise as necessary.

Original languageEnglish (US)
Pages (from-to)307-313
Number of pages7
JournalJournal of the Peripheral Nervous System
Volume15
Issue number4
DOIs
StatePublished - Dec 1 2010

Keywords

  • CIDP
  • CMT
  • Diaphragm weakness
  • GBS
  • MMN
  • Respiratory insufficiency
  • peripheral neuropathy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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