Respiratory failure in acute pancreatitis. A possible role for triglycerides

T. Kimura, J. K. Toung, S. Margolis, S. Permutt, J. L. Cameron

Research output: Contribution to journalArticle

Abstract

Respiratory failure is a frequent complication of acute pancreatitis. Two clinical studies of this association have demonstrated a high incidence of concomitant hypertriglyceridemia. Experimental studies were carried out using an ex vivo, isolated, perfused, ventilated, canine pulmonary lobe to evaluate the effects of triglyceride elevations on pulmonary mechanics and gas exchange. Control lobes perfused for a four hour period remained stable. When 5 g and 10 g of triglyceride were added to the perfusate, the lobes became grossly edematous and hemorrhagic. Intrapulmonary shunting developed (23 and 46%), weight gain occurred (130 and 189 g), effective compliance decreased, and the pressure-volume deflation curves became abnormal. Free fatty acid (FFA) levels increased markedly during the perfusion periods. When small quantities of FFA were infused directly into the pulmonary artery, similar changes, but less severe, occurred. These studies demonstrate that triglyceride elevations are capable of adversely affecting pulmonary gas exchange and mechanics. Such changes probably occur secondary to FFA release. These data thus add support to the concept that the respiratory insufficiency that is seen in acute pancreatitis could be mediated through triglyceride elevations.

Original languageEnglish (US)
Pages (from-to)509-514
Number of pages6
JournalAnnals of Surgery
Volume189
Issue number4
StatePublished - 1979

Fingerprint

Respiratory Insufficiency
Pancreatitis
Triglycerides
Nonesterified Fatty Acids
Pulmonary Gas Exchange
Mechanics
Hypertriglyceridemia
Pulmonary Artery
Compliance
Weight Gain
Canidae
Perfusion
Pressure
Lung
Incidence

ASJC Scopus subject areas

  • Surgery

Cite this

Respiratory failure in acute pancreatitis. A possible role for triglycerides. / Kimura, T.; Toung, J. K.; Margolis, S.; Permutt, S.; Cameron, J. L.

In: Annals of Surgery, Vol. 189, No. 4, 1979, p. 509-514.

Research output: Contribution to journalArticle

@article{ad0522a733b14afebdce3dceea0f8c23,
title = "Respiratory failure in acute pancreatitis. A possible role for triglycerides",
abstract = "Respiratory failure is a frequent complication of acute pancreatitis. Two clinical studies of this association have demonstrated a high incidence of concomitant hypertriglyceridemia. Experimental studies were carried out using an ex vivo, isolated, perfused, ventilated, canine pulmonary lobe to evaluate the effects of triglyceride elevations on pulmonary mechanics and gas exchange. Control lobes perfused for a four hour period remained stable. When 5 g and 10 g of triglyceride were added to the perfusate, the lobes became grossly edematous and hemorrhagic. Intrapulmonary shunting developed (23 and 46{\%}), weight gain occurred (130 and 189 g), effective compliance decreased, and the pressure-volume deflation curves became abnormal. Free fatty acid (FFA) levels increased markedly during the perfusion periods. When small quantities of FFA were infused directly into the pulmonary artery, similar changes, but less severe, occurred. These studies demonstrate that triglyceride elevations are capable of adversely affecting pulmonary gas exchange and mechanics. Such changes probably occur secondary to FFA release. These data thus add support to the concept that the respiratory insufficiency that is seen in acute pancreatitis could be mediated through triglyceride elevations.",
author = "T. Kimura and Toung, {J. K.} and S. Margolis and S. Permutt and Cameron, {J. L.}",
year = "1979",
language = "English (US)",
volume = "189",
pages = "509--514",
journal = "Annals of Surgery",
issn = "0003-4932",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Respiratory failure in acute pancreatitis. A possible role for triglycerides

AU - Kimura, T.

AU - Toung, J. K.

AU - Margolis, S.

AU - Permutt, S.

AU - Cameron, J. L.

PY - 1979

Y1 - 1979

N2 - Respiratory failure is a frequent complication of acute pancreatitis. Two clinical studies of this association have demonstrated a high incidence of concomitant hypertriglyceridemia. Experimental studies were carried out using an ex vivo, isolated, perfused, ventilated, canine pulmonary lobe to evaluate the effects of triglyceride elevations on pulmonary mechanics and gas exchange. Control lobes perfused for a four hour period remained stable. When 5 g and 10 g of triglyceride were added to the perfusate, the lobes became grossly edematous and hemorrhagic. Intrapulmonary shunting developed (23 and 46%), weight gain occurred (130 and 189 g), effective compliance decreased, and the pressure-volume deflation curves became abnormal. Free fatty acid (FFA) levels increased markedly during the perfusion periods. When small quantities of FFA were infused directly into the pulmonary artery, similar changes, but less severe, occurred. These studies demonstrate that triglyceride elevations are capable of adversely affecting pulmonary gas exchange and mechanics. Such changes probably occur secondary to FFA release. These data thus add support to the concept that the respiratory insufficiency that is seen in acute pancreatitis could be mediated through triglyceride elevations.

AB - Respiratory failure is a frequent complication of acute pancreatitis. Two clinical studies of this association have demonstrated a high incidence of concomitant hypertriglyceridemia. Experimental studies were carried out using an ex vivo, isolated, perfused, ventilated, canine pulmonary lobe to evaluate the effects of triglyceride elevations on pulmonary mechanics and gas exchange. Control lobes perfused for a four hour period remained stable. When 5 g and 10 g of triglyceride were added to the perfusate, the lobes became grossly edematous and hemorrhagic. Intrapulmonary shunting developed (23 and 46%), weight gain occurred (130 and 189 g), effective compliance decreased, and the pressure-volume deflation curves became abnormal. Free fatty acid (FFA) levels increased markedly during the perfusion periods. When small quantities of FFA were infused directly into the pulmonary artery, similar changes, but less severe, occurred. These studies demonstrate that triglyceride elevations are capable of adversely affecting pulmonary gas exchange and mechanics. Such changes probably occur secondary to FFA release. These data thus add support to the concept that the respiratory insufficiency that is seen in acute pancreatitis could be mediated through triglyceride elevations.

UR - http://www.scopus.com/inward/record.url?scp=0018773359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018773359&partnerID=8YFLogxK

M3 - Article

C2 - 443907

AN - SCOPUS:0018773359

VL - 189

SP - 509

EP - 514

JO - Annals of Surgery

JF - Annals of Surgery

SN - 0003-4932

IS - 4

ER -