Resolving metabolic abnormalities in a case of pure alexia

F. L. Silver, J. B. Chawluk, Thomas Bosley, M. Rosen, R. Dann, R. C. Sergott, A. Alavi, M. Reivich

Research output: Contribution to journalArticle

Abstract

We report resolving metabolic abnormalities corresponding to clinical improvement in a patient with pure alexia secondary to acute cerebral infarction. Local cerebral glucose metabolism (ICMRgl) was measured with positron emission tomography (PET) using 18F-fluorodeoxyglucose (18F-FDG) close to ictus and 4½ months later. Serial CTs and a subsequent MRI demonstrated small, unchanging left-hemispheric lesions involving the area of the lateral geniculate body and the splenium of the corpus callosum. PET demonstrated the evolution of the metabolic abnormality resulting from intrahemispheric (lateral geniculate) and interhemispheric (splenium) disconnection in the absence of occipital lobe infarction. This case illustrates that cerebral disconnection can result in the syndrome of pure alexia. The factors accounting for focal hypometabolism in the absence of cerebral infarction are discussed.

Original languageEnglish (US)
Pages (from-to)730-735
Number of pages6
JournalNeurology
Volume38
Issue number5
StatePublished - 1988
Externally publishedYes

Fingerprint

Pure Alexia
Cerebral Infarction
Positron-Emission Tomography
Geniculate Bodies
Occipital Lobe
Corpus Callosum
Fluorodeoxyglucose F18
Infarction
Glucose
Positron Emission Tomography

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Silver, F. L., Chawluk, J. B., Bosley, T., Rosen, M., Dann, R., Sergott, R. C., ... Reivich, M. (1988). Resolving metabolic abnormalities in a case of pure alexia. Neurology, 38(5), 730-735.

Resolving metabolic abnormalities in a case of pure alexia. / Silver, F. L.; Chawluk, J. B.; Bosley, Thomas; Rosen, M.; Dann, R.; Sergott, R. C.; Alavi, A.; Reivich, M.

In: Neurology, Vol. 38, No. 5, 1988, p. 730-735.

Research output: Contribution to journalArticle

Silver, FL, Chawluk, JB, Bosley, T, Rosen, M, Dann, R, Sergott, RC, Alavi, A & Reivich, M 1988, 'Resolving metabolic abnormalities in a case of pure alexia', Neurology, vol. 38, no. 5, pp. 730-735.
Silver FL, Chawluk JB, Bosley T, Rosen M, Dann R, Sergott RC et al. Resolving metabolic abnormalities in a case of pure alexia. Neurology. 1988;38(5):730-735.
Silver, F. L. ; Chawluk, J. B. ; Bosley, Thomas ; Rosen, M. ; Dann, R. ; Sergott, R. C. ; Alavi, A. ; Reivich, M. / Resolving metabolic abnormalities in a case of pure alexia. In: Neurology. 1988 ; Vol. 38, No. 5. pp. 730-735.
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