Resolution of intraventricular hemorrhage varies by ventricular region and dose of intraventricular thrombolytic: The clot lysis: Evaluating accelerated resolution of IVH (CLEAR IVH) program

Alastair J S Webb, Natalie L. Ullman, Sarah Mann, John Muschelli, Issam A. Awad, Daniel F Hanley

Research output: Contribution to journalArticle

Abstract

Background and Purpose-: The Clot Lysis: Evaluating Accelerated Resolution of IVH (CLEAR IVH) program is assessing the efficacy of intraventricular recombinant tissue-type plasminogen activator (rtPA) for spontaneous intraventricular hemorrhage (IVH). This subanalysis assesses the effect of dose of rtPA by region on clearance of IVH. Methods-: Sixty-four patients within 12 to 24 hours of spontaneous IVH were randomized to placebo or 0.3 mg, 1 mg, or 3 mg of rtPA twice daily through an extraventricular drain. Twelve subregions of the ventricles were scored from 0 to 4. Effect of dose on IVH clearance to 50% of baseline score was compared by survival analysis for all regions combined and by subregion. Models including ventricular region, dose, and baseline score were compared by Cox proportional hazards. Results-: IVH score reduced faster across all regions with increasing rtPA dose (clearance to 50%: log-rank P

Original languageEnglish (US)
Pages (from-to)1666-1668
Number of pages3
JournalStroke
Volume43
Issue number6
DOIs
StatePublished - Jun 2012

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Tissue Plasminogen Activator
Hemorrhage
Survival Analysis
Placebos

Keywords

  • intraventricular hemorrhage
  • randomized controlled trials
  • thrombolysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Resolution of intraventricular hemorrhage varies by ventricular region and dose of intraventricular thrombolytic : The clot lysis: Evaluating accelerated resolution of IVH (CLEAR IVH) program. / Webb, Alastair J S; Ullman, Natalie L.; Mann, Sarah; Muschelli, John; Awad, Issam A.; Hanley, Daniel F.

In: Stroke, Vol. 43, No. 6, 06.2012, p. 1666-1668.

Research output: Contribution to journalArticle

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abstract = "Background and Purpose-: The Clot Lysis: Evaluating Accelerated Resolution of IVH (CLEAR IVH) program is assessing the efficacy of intraventricular recombinant tissue-type plasminogen activator (rtPA) for spontaneous intraventricular hemorrhage (IVH). This subanalysis assesses the effect of dose of rtPA by region on clearance of IVH. Methods-: Sixty-four patients within 12 to 24 hours of spontaneous IVH were randomized to placebo or 0.3 mg, 1 mg, or 3 mg of rtPA twice daily through an extraventricular drain. Twelve subregions of the ventricles were scored from 0 to 4. Effect of dose on IVH clearance to 50{\%} of baseline score was compared by survival analysis for all regions combined and by subregion. Models including ventricular region, dose, and baseline score were compared by Cox proportional hazards. Results-: IVH score reduced faster across all regions with increasing rtPA dose (clearance to 50{\%}: log-rank P",
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