TY - GEN
T1 - Resolution modeled PET image reconstruction incorporating space-variance of positron range
T2 - 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
AU - Rahmim, Arman
AU - Tang, Jing
AU - Lodge, Martin A.
AU - Lashkari, Sarah
AU - Mohammad, R. Ay
AU - Bengel, Frank M.
PY - 2008
Y1 - 2008
N2 - This work explores application of a novel resolution modeling technique that incorporates the spatial-variant, medium-dependent nature of positron range. We have hypothesized that given the varied positron ranges in different mediums such as lung, blood and bone, incorporation of such differences could lead to further improved image qualities and clinical and quantitative tasks. In fact, we have quantified the relationship between the distribution of positrons annihilated in a certain medium and the amount by which 511keV photons are attenuated in that medium. Subsequently, we have shown that is possible to utilize mu-map images generated from transmission or CT imaging to arrive at so-called C-maps and a-maps that describe how positrons are annihilated in the field-of-view. Using Monte-Carlo simulation of Rb-82 myocardial perfusion imaging, we showed that while the extension from space-invariant to space-variant modeling of Rb-82 positron range showed certain improvements in myocardial defect contrast, when taking the relation between the lung and the myocardium into account, very significant qualitative and quantitative improvements were obtained.
AB - This work explores application of a novel resolution modeling technique that incorporates the spatial-variant, medium-dependent nature of positron range. We have hypothesized that given the varied positron ranges in different mediums such as lung, blood and bone, incorporation of such differences could lead to further improved image qualities and clinical and quantitative tasks. In fact, we have quantified the relationship between the distribution of positrons annihilated in a certain medium and the amount by which 511keV photons are attenuated in that medium. Subsequently, we have shown that is possible to utilize mu-map images generated from transmission or CT imaging to arrive at so-called C-maps and a-maps that describe how positrons are annihilated in the field-of-view. Using Monte-Carlo simulation of Rb-82 myocardial perfusion imaging, we showed that while the extension from space-invariant to space-variant modeling of Rb-82 positron range showed certain improvements in myocardial defect contrast, when taking the relation between the lung and the myocardium into account, very significant qualitative and quantitative improvements were obtained.
UR - http://www.scopus.com/inward/record.url?scp=67649148613&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67649148613&partnerID=8YFLogxK
U2 - 10.1109/NSSMIC.2008.4774108
DO - 10.1109/NSSMIC.2008.4774108
M3 - Conference contribution
AN - SCOPUS:67649148613
SN - 9781424427154
T3 - IEEE Nuclear Science Symposium Conference Record
SP - 3643
EP - 3650
BT - 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
Y2 - 19 October 2008 through 25 October 2008
ER -