Resolution modeled PET image reconstruction incorporating space-variance of positron range: Rubidium-82 cardiac PET imaging

Arman Rahmim, Jing Tang, Martin A. Lodge, Sarah Lashkari, R. Ay Mohammad, Frank Michael Bengel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This work explores application of a novel resolution modeling technique that incorporates the spatial-variant, medium-dependent nature of positron range. We have hypothesized that given the varied positron ranges in different mediums such as lung, blood and bone, incorporation of such differences could lead to further improved image qualities and clinical and quantitative tasks. In fact, we have quantified the relationship between the distribution of positrons annihilated in a certain medium and the amount by which 511keV photons are attenuated in that medium. Subsequently, we have shown that is possible to utilize mu-map images generated from transmission or CT imaging to arrive at so-called C-maps and a-maps that describe how positrons are annihilated in the field-of-view. Using Monte-Carlo simulation of Rb-82 myocardial perfusion imaging, we showed that while the extension from space-invariant to space-variant modeling of Rb-82 positron range showed certain improvements in myocardial defect contrast, when taking the relation between the lung and the myocardium into account, very significant qualitative and quantitative improvements were obtained.

Original languageEnglish (US)
Title of host publication2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
Pages3643-3650
Number of pages8
DOIs
StatePublished - Dec 1 2008
Event2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 - Dresden, Germany
Duration: Oct 19 2008Oct 25 2008

Publication series

NameIEEE Nuclear Science Symposium Conference Record
ISSN (Print)1095-7863

Other

Other2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
CountryGermany
CityDresden
Period10/19/0810/25/08

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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    Rahmim, A., Tang, J., Lodge, M. A., Lashkari, S., Mohammad, R. A., & Bengel, F. M. (2008). Resolution modeled PET image reconstruction incorporating space-variance of positron range: Rubidium-82 cardiac PET imaging. In 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 (pp. 3643-3650). [4774108] (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2008.4774108