TY - JOUR
T1 - Resolution enhancement of wide-field interferometric microscopy by coupled deep autoencoders
AU - Işil, Çaǧatay
AU - Yorulmaz, Mustafa
AU - Solmaz, Berkan
AU - Turhan, Adil Burak
AU - Yurdakul, Celalettin
AU - Ünlü, Selim
AU - Ozbay, Ekmel
AU - Koç, Aykut
N1 - Publisher Copyright:
© 2018 Optical Society of America.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Wide-field interferometric microscopy is a highly sensitive, label-free, and low-cost biosensing imaging technique capable of visualizing individual biological nanoparticles such as viral pathogens and exosomes. However, further resolution enhancement is necessary to increase detection and classification accuracy of subdiffraction-limited nanoparticles. In this study, we propose a deep-learning approach, based on coupled deep autoencoders, to improve resolution of images of L-shaped nanostructures. During training, our method utilizes microscope image patches and their corresponding manual truth image patches in order to learn the transformation between them. Following training, the designed network reconstructs denoised and resolution-enhanced image patches for unseen input.
AB - Wide-field interferometric microscopy is a highly sensitive, label-free, and low-cost biosensing imaging technique capable of visualizing individual biological nanoparticles such as viral pathogens and exosomes. However, further resolution enhancement is necessary to increase detection and classification accuracy of subdiffraction-limited nanoparticles. In this study, we propose a deep-learning approach, based on coupled deep autoencoders, to improve resolution of images of L-shaped nanostructures. During training, our method utilizes microscope image patches and their corresponding manual truth image patches in order to learn the transformation between them. Following training, the designed network reconstructs denoised and resolution-enhanced image patches for unseen input.
UR - http://www.scopus.com/inward/record.url?scp=85044867705&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044867705&partnerID=8YFLogxK
U2 - 10.1364/AO.57.002545
DO - 10.1364/AO.57.002545
M3 - Article
C2 - 29714238
AN - SCOPUS:85044867705
SN - 1559-128X
VL - 57
SP - 2545
EP - 2552
JO - Applied Optics
JF - Applied Optics
IS - 10
ER -