Resistive and pulsatile arterial hemodynamics and cardiovascular events: The multiethnic study of atherosclerosis

Scott M. Lilly, David Jacobs, David A. Bluemke, Daniel Duprez, Payman Zamani, Julio Chirinos

Research output: Contribution to journalArticle

Abstract

Background-Arterial blood pressure is dependent on interactions between the heart and arteries. Resistive and pulsatile components of arterial load can be assessed by systemic vascular resistance (SVR, a microvascular property) and the ratio of stroke volume to pulse pressure (a surrogate of total arterial compliance, TAC), respectively. The relationship between arterial function and cardiovascular events in populations without cardiovascular disease is unknown. Methods and Results-We studied 4806 adults enrolled in the Multi-Ethnic Study of Atherosclerosis who were free of clinical cardiovascular disease at baseline. SVR and stroke volume/pulse pressure (SV/PP) were derived by sphygmomanometry and magnetic resonance imaging. The relationship between these measures of arterial function and incident cardiovascular events was assessed using Cox regression. With a mean follow-up of 7.5 years, cardiovascular events occurred in 358 participants (7.4%). There was no relationship between SVR and subsequent cardiovascular events. However, increased stroke volume/pulse pressure was associated with reduced event rate in unadjusted (hazard ratio=0.67, 95% CI=0.58 to 0.77, P

Original languageEnglish (US)
Article number001223
JournalJournal of the American Heart Association
Volume3
Issue number6
DOIs
StatePublished - 2014
Externally publishedYes

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Stroke Volume
Atherosclerosis
Hemodynamics
Blood Pressure
Cardiovascular Diseases
Vascular Resistance
Compliance
Arterial Pressure
Arteries
Magnetic Resonance Imaging
Population

Keywords

  • Arterial compliance
  • Microvascular
  • Pulsatile hemodynamics
  • Resistance

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Resistive and pulsatile arterial hemodynamics and cardiovascular events : The multiethnic study of atherosclerosis. / Lilly, Scott M.; Jacobs, David; Bluemke, David A.; Duprez, Daniel; Zamani, Payman; Chirinos, Julio.

In: Journal of the American Heart Association, Vol. 3, No. 6, 001223, 2014.

Research output: Contribution to journalArticle

Lilly, Scott M. ; Jacobs, David ; Bluemke, David A. ; Duprez, Daniel ; Zamani, Payman ; Chirinos, Julio. / Resistive and pulsatile arterial hemodynamics and cardiovascular events : The multiethnic study of atherosclerosis. In: Journal of the American Heart Association. 2014 ; Vol. 3, No. 6.
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