Resistant Microascus cirrosus pneumonia can be treated with a combination of surgery, multiple anti-fungal agents and a growth factor

Celalettin Ustun, Gerwin Huls, Marc Stewart, Kieren Marr

Research output: Contribution to journalArticle

Abstract

A 49-year old male with acute myelogenous leukemia relapsed eight years post allogeneic bone marrow transplantation. The patient received induction chemotherapy causing prolonged neutropenia. The patient developed pneumonia for which empirical antibacterial and antifungal therapy were started. The patient underwent a video-assisted thorocascopy with near complete resection of the lesion because of poor response to treatment. Microascus cirrosus was identified in the tissue. In vitro susceptibility test to different antifungal agents showed M. cirrosus was very resistant. The patient is undergoing second allogeneic transplant with improved pneumonia resulting from a combination of treatment for fungal infection, which included surgery, antifungal agents, and granulocyte-colony stimulating factor. The Microascus genus rarely causes invasive fungal infection in humans and can be very difficult to treat because of the resistance to available antifungal agents.

Original languageEnglish (US)
Pages (from-to)299-302
Number of pages4
JournalMycopathologia
Volume162
Issue number4
DOIs
StatePublished - Oct 2006
Externally publishedYes

Fingerprint

growth factors
pneumonia
Antifungal Agents
Intercellular Signaling Peptides and Proteins
Pneumonia
surgery
granulocyte colony-stimulating factor
bone marrow transplant
neutropenia
Induction Chemotherapy
Mycoses
Homologous Transplantation
Granulocyte Colony-Stimulating Factor
resection
Neutropenia
Bone Marrow Transplantation
leukemia
Acute Myeloid Leukemia
lesions (animal)
infection

Keywords

  • Bone marrow transplantation
  • Fungal infection
  • Microascus cirrosus
  • Pneumonia
  • Scopulariopsis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

Resistant Microascus cirrosus pneumonia can be treated with a combination of surgery, multiple anti-fungal agents and a growth factor. / Ustun, Celalettin; Huls, Gerwin; Stewart, Marc; Marr, Kieren.

In: Mycopathologia, Vol. 162, No. 4, 10.2006, p. 299-302.

Research output: Contribution to journalArticle

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