Resistance to recombinant human granulocyte colony-stimulating factor in neonatal alloimmune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies.

Akhil Maheshwari, Robert D. Christensen, Darlene A. Calhoun

Research output: Contribution to journalArticle

Abstract

Neonatal alloimmune neutropenia is the neutrophil counterpart of the erythrocyte disorder of hemolytic disease of the newborn. Fetal neutrophil antigens, which are inherited from the father but foreign to the pregnant mother, provoke the formation of maternal antibodies, which, on transplacental passage, cause fetal/neonatal neutropenia. Because infants with this disorder are at a higher risk of infection, recombinant hematopoietic growth factors, such as recombinant human granulocyte colony-stimulating factor, have been tried, with generally good results, to treat those with severe and prolonged neutropenia. We report a neonate who had neonatal alloimmune neutropenia associated with antibodies directed against human neutrophil antigen-2a (NB1) and initially failed to respond to even very high doses of recombinant human granulocyte colony-stimulating factor but eventually had a therapeutic response.

Original languageEnglish (US)
JournalPediatrics
Volume109
Issue number4
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

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Granulocyte Colony-Stimulating Factor
Neutropenia
Neutrophils
Antigens
Antibodies
Mothers
Fetal Erythroblastosis
Fathers
Antibody Formation
Intercellular Signaling Peptides and Proteins
Erythrocytes
Newborn Infant
Infection
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Resistance to recombinant human granulocyte colony-stimulating factor in neonatal alloimmune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies. / Maheshwari, Akhil; Christensen, Robert D.; Calhoun, Darlene A.

In: Pediatrics, Vol. 109, No. 4, 01.01.2002.

Research output: Contribution to journalArticle

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