Resistance after single-dose nevirapine prophylaxis emerges in a high proportion of Malawian newborns

Susan Eshleman, Donald R. Hoover, Shu Chen, Sarah E. Hudelson, Laura A. Guay, Anthony Mwatha, Susan A. Fiscus, Francis Mmiro, Philippa Musoke, J. Brooks Jackson, Newton Kumwenda, Taha E Taha

Research output: Contribution to journalArticle

Abstract

The administration of single-dose nevirapine to women in labor and their infants can prevent HIV-1 mother-to-child transmission. We examined nevirapine resistance in infants -who -were HIV-1 infected despite single-dose nevirapine prophylaxis, including 18 Ugandan infants (HIVNET 012 trial, nine subtype A and nine subtype D) and 23 Malawian infants (NVAZ trial, all subtype C). Nevirapine resistance was more frequent in infants with subtype C than with subtypes A and D (87 versus 50%, P = 0.016).

Original languageEnglish (US)
Pages (from-to)2167-2169
Number of pages3
JournalAIDS
Volume19
Issue number18
StatePublished - Dec 2005

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Nevirapine
Newborn Infant
HIV-1
Mothers

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Eshleman, S., Hoover, D. R., Chen, S., Hudelson, S. E., Guay, L. A., Mwatha, A., ... Taha, T. E. (2005). Resistance after single-dose nevirapine prophylaxis emerges in a high proportion of Malawian newborns. AIDS, 19(18), 2167-2169.

Resistance after single-dose nevirapine prophylaxis emerges in a high proportion of Malawian newborns. / Eshleman, Susan; Hoover, Donald R.; Chen, Shu; Hudelson, Sarah E.; Guay, Laura A.; Mwatha, Anthony; Fiscus, Susan A.; Mmiro, Francis; Musoke, Philippa; Jackson, J. Brooks; Kumwenda, Newton; Taha, Taha E.

In: AIDS, Vol. 19, No. 18, 12.2005, p. 2167-2169.

Research output: Contribution to journalArticle

Eshleman, S, Hoover, DR, Chen, S, Hudelson, SE, Guay, LA, Mwatha, A, Fiscus, SA, Mmiro, F, Musoke, P, Jackson, JB, Kumwenda, N & Taha, TE 2005, 'Resistance after single-dose nevirapine prophylaxis emerges in a high proportion of Malawian newborns', AIDS, vol. 19, no. 18, pp. 2167-2169.
Eshleman S, Hoover DR, Chen S, Hudelson SE, Guay LA, Mwatha A et al. Resistance after single-dose nevirapine prophylaxis emerges in a high proportion of Malawian newborns. AIDS. 2005 Dec;19(18):2167-2169.
Eshleman, Susan ; Hoover, Donald R. ; Chen, Shu ; Hudelson, Sarah E. ; Guay, Laura A. ; Mwatha, Anthony ; Fiscus, Susan A. ; Mmiro, Francis ; Musoke, Philippa ; Jackson, J. Brooks ; Kumwenda, Newton ; Taha, Taha E. / Resistance after single-dose nevirapine prophylaxis emerges in a high proportion of Malawian newborns. In: AIDS. 2005 ; Vol. 19, No. 18. pp. 2167-2169.
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