TY - JOUR
T1 - Residual Motor Signal in Long-Term Human Severed Peripheral Nerves and Feasibility of Neural Signal-Controlled Artificial Limb
AU - Jia, Xiaofeng
AU - Koenig, Matthew A.
AU - Zhang, Xiaowen
AU - Zhang, Jian
AU - Chen, Tongyi
AU - Chen, Zhongwei
PY - 2007/5
Y1 - 2007/5
N2 - Purpose: The residual motor pathways after amputation have not been fully elucidated. We sampled potentials from peripheral nerve stumps with intrafascicular electrodes to study residual motor transmission and explore the feasibility of nerve signal-controlled artificial limbs. Methods: Six intrafascicular electrodes were inserted into the ulnar, radial, and median nerves in the stump of an amputee. An electrode was placed outside the fascicle as a reference. Potentials from 4 of the 6 electrodes per trial were monitored using a 4-channel electromyogram machine, and 32 groups of electrophysiologic tests were conducted under volitional control. Actions included finger extension and flexion, forearm pronation and supination, and wrist extension and flexion. Each action was carried out with light, intermediate, and full efforts. Then, 2 of 6 electrodes randomly chosen per trial were interfaced to a nerve signal-controlled artificial limb. Finger extension and flexion of the prosthesis were tested under volitional control. Results: The volitional motor nerve potentials uniquely associated with the missing limb were recorded successfully with intrafascicular electrodes. The signal amplitude from the radial nerve was 5.5 μV ± 0.8 (mean ± SD), which was greater than the amplitudes from the ulnar (2.5 μV ± 0.4) and median (2.2 μV ± 0.3) nerves. Under volitional control of the subject, finger extension of the artificial limb was triggered by the radial nerve signal, but the remaining actions were unsuccessful. Conclusions: The long-term amputee was able to generate motor neuron activity related to phantom limb movement. Intrafascicular electrodes can be used to monitor residual motor nerve activity in the stump, and the amplitude may predict successful control of artificial limbs.
AB - Purpose: The residual motor pathways after amputation have not been fully elucidated. We sampled potentials from peripheral nerve stumps with intrafascicular electrodes to study residual motor transmission and explore the feasibility of nerve signal-controlled artificial limbs. Methods: Six intrafascicular electrodes were inserted into the ulnar, radial, and median nerves in the stump of an amputee. An electrode was placed outside the fascicle as a reference. Potentials from 4 of the 6 electrodes per trial were monitored using a 4-channel electromyogram machine, and 32 groups of electrophysiologic tests were conducted under volitional control. Actions included finger extension and flexion, forearm pronation and supination, and wrist extension and flexion. Each action was carried out with light, intermediate, and full efforts. Then, 2 of 6 electrodes randomly chosen per trial were interfaced to a nerve signal-controlled artificial limb. Finger extension and flexion of the prosthesis were tested under volitional control. Results: The volitional motor nerve potentials uniquely associated with the missing limb were recorded successfully with intrafascicular electrodes. The signal amplitude from the radial nerve was 5.5 μV ± 0.8 (mean ± SD), which was greater than the amplitudes from the ulnar (2.5 μV ± 0.4) and median (2.2 μV ± 0.3) nerves. Under volitional control of the subject, finger extension of the artificial limb was triggered by the radial nerve signal, but the remaining actions were unsuccessful. Conclusions: The long-term amputee was able to generate motor neuron activity related to phantom limb movement. Intrafascicular electrodes can be used to monitor residual motor nerve activity in the stump, and the amplitude may predict successful control of artificial limbs.
KW - Artificial limb
KW - human
KW - intrafascicular electrode
KW - motor signal
KW - peripheral nerve
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U2 - 10.1016/j.jhsa.2007.02.021
DO - 10.1016/j.jhsa.2007.02.021
M3 - Article
C2 - 17482005
AN - SCOPUS:34247563831
SN - 0363-5023
VL - 32
SP - 657
EP - 666
JO - Journal of Hand Surgery
JF - Journal of Hand Surgery
IS - 5
ER -