Residual Motor Signal in Long-Term Human Severed Peripheral Nerves and Feasibility of Neural Signal-Controlled Artificial Limb

Xiaofeng Jia, Matthew A. Koenig, Xiaowen Zhang, Jian Zhang, Tongyi Chen, Zhongwei Chen

Research output: Contribution to journalArticle

Abstract

Purpose: The residual motor pathways after amputation have not been fully elucidated. We sampled potentials from peripheral nerve stumps with intrafascicular electrodes to study residual motor transmission and explore the feasibility of nerve signal-controlled artificial limbs. Methods: Six intrafascicular electrodes were inserted into the ulnar, radial, and median nerves in the stump of an amputee. An electrode was placed outside the fascicle as a reference. Potentials from 4 of the 6 electrodes per trial were monitored using a 4-channel electromyogram machine, and 32 groups of electrophysiologic tests were conducted under volitional control. Actions included finger extension and flexion, forearm pronation and supination, and wrist extension and flexion. Each action was carried out with light, intermediate, and full efforts. Then, 2 of 6 electrodes randomly chosen per trial were interfaced to a nerve signal-controlled artificial limb. Finger extension and flexion of the prosthesis were tested under volitional control. Results: The volitional motor nerve potentials uniquely associated with the missing limb were recorded successfully with intrafascicular electrodes. The signal amplitude from the radial nerve was 5.5 μV ± 0.8 (mean ± SD), which was greater than the amplitudes from the ulnar (2.5 μV ± 0.4) and median (2.2 μV ± 0.3) nerves. Under volitional control of the subject, finger extension of the artificial limb was triggered by the radial nerve signal, but the remaining actions were unsuccessful. Conclusions: The long-term amputee was able to generate motor neuron activity related to phantom limb movement. Intrafascicular electrodes can be used to monitor residual motor nerve activity in the stump, and the amplitude may predict successful control of artificial limbs.

Original languageEnglish (US)
Pages (from-to)657-666
Number of pages10
JournalJournal of Hand Surgery
Volume32
Issue number5
DOIs
StatePublished - May 1 2007

Keywords

  • Artificial limb
  • human
  • intrafascicular electrode
  • motor signal
  • peripheral nerve

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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