Residual Kidney Function: Implications in the Era of Personalized Medicine

Tariq Shafi, Surekha Mullangi, Stephanie M. Toth-Manikowski, Seungyoung Hwang, Wieneke M. Michels

Research output: Contribution to journalArticle


The association of residual kidney function (RKF) with improved outcomes in peritoneal dialysis and hemodialysis patients is now widely recognized. RKF provides substantial volume and solute clearance even after dialysis initiation. In particular, RKF provides clearance of nonurea solutes, many of which are potential uremic toxins and not effectively removed by conventional hemodialysis. The presence of RKF provides a distinct advantage to incident dialysis patients and is an opportunity for nephrologists to individualize dialysis treatments tailored to their patients' unique solute, volume, and quality of life needs. The benefits of RKF present the opportunity to personalize the management of uremia.

Original languageEnglish (US)
JournalSeminars in Dialysis
StateAccepted/In press - 2017


ASJC Scopus subject areas

  • Nephrology

Cite this

Shafi, T., Mullangi, S., Toth-Manikowski, S. M., Hwang, S., & Michels, W. M. (Accepted/In press). Residual Kidney Function: Implications in the Era of Personalized Medicine. Seminars in Dialysis.