TY - JOUR
T1 - Residual Angle Closure One Year After Laser Peripheral Iridotomy in Primary Angle Closure Suspects
AU - Baskaran, Mani
AU - Yang, Elizabeth
AU - Trikha, Sameer
AU - Kumar, Rajesh S.
AU - Wong, Hon Tym
AU - He, Mingguang
AU - Chew, Paul T.K.
AU - Foster, Paul J.
AU - Friedman, David
AU - Aung, Tin
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/11
Y1 - 2017/11
N2 - Purpose To determine the incidence and baseline clinical and anterior segment optical coherence tomography (AS-OCT) predictors associated with residual angle closure as assessed by gonioscopy 1 year after laser peripheral iridotomy (LPI) in primary angle closure suspects (PACS). Design Subanalysis of randomized controlled trial data. Methods AS-OCT images from 181 PACS subjects ≥50 years of age were analyzed using customized software before and 1 year after LPI. Other parameters assessed were intraocular pressure (IOP) and axial length (Axl). Residual angle closure was defined as the inability to see the posterior trabecular meshwork for at least 2 quadrants on gonioscopy after LPI. Multivariate regression analysis determined the baseline predictors of residual angle closure 1 year after LPI. Results The mean age of participants was 62.4 (standard deviation 9.9) years. The majority were female (137, 75.7%) and Chinese (174, 96.1%). At 1 year post LPI, 148 (81.8%) subjects had gonioscopic residual angle closure. Univariate analysis showed that baseline Axl, anterior chamber area, anterior chamber volume, angle opening distance at 750 μm from the scleral spur, and angle recess area were smaller while baseline lens vault and iris curvature were larger in residual angle closure subjects (all P <.05). Multivariate analysis revealed that baseline iris volume (B = −0.08, P =.035) and baseline IOP (B = 0.23, P =.032) were predictors for residual angle closure. Conclusions One year after LPI, >80% of PACS had gonioscopic residual angle closure. Greater baseline iris volume and higher IOP at baseline are independent risk factors for residual gonioscopic angle closure.
AB - Purpose To determine the incidence and baseline clinical and anterior segment optical coherence tomography (AS-OCT) predictors associated with residual angle closure as assessed by gonioscopy 1 year after laser peripheral iridotomy (LPI) in primary angle closure suspects (PACS). Design Subanalysis of randomized controlled trial data. Methods AS-OCT images from 181 PACS subjects ≥50 years of age were analyzed using customized software before and 1 year after LPI. Other parameters assessed were intraocular pressure (IOP) and axial length (Axl). Residual angle closure was defined as the inability to see the posterior trabecular meshwork for at least 2 quadrants on gonioscopy after LPI. Multivariate regression analysis determined the baseline predictors of residual angle closure 1 year after LPI. Results The mean age of participants was 62.4 (standard deviation 9.9) years. The majority were female (137, 75.7%) and Chinese (174, 96.1%). At 1 year post LPI, 148 (81.8%) subjects had gonioscopic residual angle closure. Univariate analysis showed that baseline Axl, anterior chamber area, anterior chamber volume, angle opening distance at 750 μm from the scleral spur, and angle recess area were smaller while baseline lens vault and iris curvature were larger in residual angle closure subjects (all P <.05). Multivariate analysis revealed that baseline iris volume (B = −0.08, P =.035) and baseline IOP (B = 0.23, P =.032) were predictors for residual angle closure. Conclusions One year after LPI, >80% of PACS had gonioscopic residual angle closure. Greater baseline iris volume and higher IOP at baseline are independent risk factors for residual gonioscopic angle closure.
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U2 - 10.1016/j.ajo.2017.08.016
DO - 10.1016/j.ajo.2017.08.016
M3 - Article
C2 - 28887116
AN - SCOPUS:85029765542
SN - 0002-9394
VL - 183
SP - 111
EP - 117
JO - American journal of ophthalmology
JF - American journal of ophthalmology
ER -