Resection of recurrent pulmonary metastases in patients with soft-tissue sarcomas

W. E. Rizzoni, H. I. Pass, M. N. Wesley, S. A. Rosenberg, J. A. Roth

Research output: Contribution to journalArticle

Abstract

Survival benefit and prognostic factors useful for patient selection have not been previously analyzed for patients with recurrent pulmonary metastases from soft-tissue sarcomas. Twenty-nine patients in our study had two or more resections of pulmonary metastases from 1976 to 1983. There were no operative deaths and three complications for 40 operations (7.5%). Factors predictive of increased survival following the second resection of pulmonary metastases were resectability and a disease-free interval of greater than six months from the first thoracotomy to the second recurrence in the lung. The tumor doubling time of the first recurrence and the presence of three or fewer nodules on full-lung tomography before the first thoracotomy, which were predictors of survival following initial resection, also predicted survival following subsequent resections. Overall median survival following the second resection was 14.5 months (22% overall three-year survival). The postresection actuarial survival curves for patients undergoing 1, 2, or 3 or more resections were not significantly different. Our findings demonstrate that patients undergoing repeated resections of pulmonary metastases from soft-tissue sarcomas can achieve prolonged survival.

Original languageEnglish (US)
Pages (from-to)1248-1252
Number of pages5
JournalArchives of Surgery
Volume121
Issue number11
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Sarcoma
Neoplasm Metastasis
Lung
Survival
Thoracotomy
Recurrence
Patient Selection
Tomography
Neoplasms

ASJC Scopus subject areas

  • Surgery

Cite this

Rizzoni, W. E., Pass, H. I., Wesley, M. N., Rosenberg, S. A., & Roth, J. A. (1986). Resection of recurrent pulmonary metastases in patients with soft-tissue sarcomas. Archives of Surgery, 121(11), 1248-1252. https://doi.org/10.1001/archsurg.121.11.1248

Resection of recurrent pulmonary metastases in patients with soft-tissue sarcomas. / Rizzoni, W. E.; Pass, H. I.; Wesley, M. N.; Rosenberg, S. A.; Roth, J. A.

In: Archives of Surgery, Vol. 121, No. 11, 1986, p. 1248-1252.

Research output: Contribution to journalArticle

Rizzoni, WE, Pass, HI, Wesley, MN, Rosenberg, SA & Roth, JA 1986, 'Resection of recurrent pulmonary metastases in patients with soft-tissue sarcomas', Archives of Surgery, vol. 121, no. 11, pp. 1248-1252. https://doi.org/10.1001/archsurg.121.11.1248
Rizzoni, W. E. ; Pass, H. I. ; Wesley, M. N. ; Rosenberg, S. A. ; Roth, J. A. / Resection of recurrent pulmonary metastases in patients with soft-tissue sarcomas. In: Archives of Surgery. 1986 ; Vol. 121, No. 11. pp. 1248-1252.
@article{89ffd2dfd93648c085b73e5500534745,
title = "Resection of recurrent pulmonary metastases in patients with soft-tissue sarcomas",
abstract = "Survival benefit and prognostic factors useful for patient selection have not been previously analyzed for patients with recurrent pulmonary metastases from soft-tissue sarcomas. Twenty-nine patients in our study had two or more resections of pulmonary metastases from 1976 to 1983. There were no operative deaths and three complications for 40 operations (7.5{\%}). Factors predictive of increased survival following the second resection of pulmonary metastases were resectability and a disease-free interval of greater than six months from the first thoracotomy to the second recurrence in the lung. The tumor doubling time of the first recurrence and the presence of three or fewer nodules on full-lung tomography before the first thoracotomy, which were predictors of survival following initial resection, also predicted survival following subsequent resections. Overall median survival following the second resection was 14.5 months (22{\%} overall three-year survival). The postresection actuarial survival curves for patients undergoing 1, 2, or 3 or more resections were not significantly different. Our findings demonstrate that patients undergoing repeated resections of pulmonary metastases from soft-tissue sarcomas can achieve prolonged survival.",
author = "Rizzoni, {W. E.} and Pass, {H. I.} and Wesley, {M. N.} and Rosenberg, {S. A.} and Roth, {J. A.}",
year = "1986",
doi = "10.1001/archsurg.121.11.1248",
language = "English (US)",
volume = "121",
pages = "1248--1252",
journal = "JAMA Surgery",
issn = "2168-6254",
publisher = "American Medical Association",
number = "11",

}

TY - JOUR

T1 - Resection of recurrent pulmonary metastases in patients with soft-tissue sarcomas

AU - Rizzoni, W. E.

AU - Pass, H. I.

AU - Wesley, M. N.

AU - Rosenberg, S. A.

AU - Roth, J. A.

PY - 1986

Y1 - 1986

N2 - Survival benefit and prognostic factors useful for patient selection have not been previously analyzed for patients with recurrent pulmonary metastases from soft-tissue sarcomas. Twenty-nine patients in our study had two or more resections of pulmonary metastases from 1976 to 1983. There were no operative deaths and three complications for 40 operations (7.5%). Factors predictive of increased survival following the second resection of pulmonary metastases were resectability and a disease-free interval of greater than six months from the first thoracotomy to the second recurrence in the lung. The tumor doubling time of the first recurrence and the presence of three or fewer nodules on full-lung tomography before the first thoracotomy, which were predictors of survival following initial resection, also predicted survival following subsequent resections. Overall median survival following the second resection was 14.5 months (22% overall three-year survival). The postresection actuarial survival curves for patients undergoing 1, 2, or 3 or more resections were not significantly different. Our findings demonstrate that patients undergoing repeated resections of pulmonary metastases from soft-tissue sarcomas can achieve prolonged survival.

AB - Survival benefit and prognostic factors useful for patient selection have not been previously analyzed for patients with recurrent pulmonary metastases from soft-tissue sarcomas. Twenty-nine patients in our study had two or more resections of pulmonary metastases from 1976 to 1983. There were no operative deaths and three complications for 40 operations (7.5%). Factors predictive of increased survival following the second resection of pulmonary metastases were resectability and a disease-free interval of greater than six months from the first thoracotomy to the second recurrence in the lung. The tumor doubling time of the first recurrence and the presence of three or fewer nodules on full-lung tomography before the first thoracotomy, which were predictors of survival following initial resection, also predicted survival following subsequent resections. Overall median survival following the second resection was 14.5 months (22% overall three-year survival). The postresection actuarial survival curves for patients undergoing 1, 2, or 3 or more resections were not significantly different. Our findings demonstrate that patients undergoing repeated resections of pulmonary metastases from soft-tissue sarcomas can achieve prolonged survival.

UR - http://www.scopus.com/inward/record.url?scp=0023013630&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023013630&partnerID=8YFLogxK

U2 - 10.1001/archsurg.121.11.1248

DO - 10.1001/archsurg.121.11.1248

M3 - Article

VL - 121

SP - 1248

EP - 1252

JO - JAMA Surgery

JF - JAMA Surgery

SN - 2168-6254

IS - 11

ER -