Research priorities in pathophysiology for sleep-disordered breathing in patients with chronic obstructive pulmonary disease

An Official American Thoracic Society Research Statement

ATS Assembly on Sleep and Respiratory Neurobiology

Research output: Contribution to journalArticle

Abstract

Background: Obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) are common conditions; the co-occurrence of these diseases, called the overlap syndrome (OVS), has been associated with poor health outcomes. Purpose: The purpose of this Official American Thoracic Society Research Statement is to describe pathophysiology, epidemiology, outcomes, diagnostic metrics, and treatment of OVS, as well as to identify important gaps in knowledge and make recommendations for future research. Methods: Clinicians and researchers with expertise in sleep medicine, pulmonary medicine, or both were invited to participate. Topics were divided among the participants according to their interest and expertise. A literature search was conducted; the search was not a formal systematic review. Evidence was considered and supplemented with the panelists' nonsystematic clinical observations. Important knowledge gaps were identified. Results: Recommendations for research to fill existing knowledge gaps were made. The recommendations were formulated by discussion and consensus. Conclusions: Many important questions about OVS exist. This American Thoracic Society Research Statement highlights the types of research that leading clinicians and researchers believe will have the greatest impact on better understanding the spectrum of disease, improving diagnosis, and optimizing therapy.

Original languageEnglish (US)
Pages (from-to)289-299
Number of pages11
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume197
Issue number3
DOIs
StatePublished - Feb 1 2018

Fingerprint

Sleep Apnea Syndromes
Chronic Obstructive Pulmonary Disease
Research
Research Personnel
Pulmonary Medicine
Obstructive Sleep Apnea
Consensus
Sleep
Epidemiology
Medicine
Health
Therapeutics

Keywords

  • Apnea
  • COPD
  • Hypoxia
  • Lung
  • Sleep

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

@article{baa75a733a4a4fc9addb43bfb93a7c7b,
title = "Research priorities in pathophysiology for sleep-disordered breathing in patients with chronic obstructive pulmonary disease: An Official American Thoracic Society Research Statement",
abstract = "Background: Obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) are common conditions; the co-occurrence of these diseases, called the overlap syndrome (OVS), has been associated with poor health outcomes. Purpose: The purpose of this Official American Thoracic Society Research Statement is to describe pathophysiology, epidemiology, outcomes, diagnostic metrics, and treatment of OVS, as well as to identify important gaps in knowledge and make recommendations for future research. Methods: Clinicians and researchers with expertise in sleep medicine, pulmonary medicine, or both were invited to participate. Topics were divided among the participants according to their interest and expertise. A literature search was conducted; the search was not a formal systematic review. Evidence was considered and supplemented with the panelists' nonsystematic clinical observations. Important knowledge gaps were identified. Results: Recommendations for research to fill existing knowledge gaps were made. The recommendations were formulated by discussion and consensus. Conclusions: Many important questions about OVS exist. This American Thoracic Society Research Statement highlights the types of research that leading clinicians and researchers believe will have the greatest impact on better understanding the spectrum of disease, improving diagnosis, and optimizing therapy.",
keywords = "Apnea, COPD, Hypoxia, Lung, Sleep",
author = "{ATS Assembly on Sleep and Respiratory Neurobiology} and Atul Malhotra and Schwartz, {Alan R.} and Hartmut Schneider and Owens, {Robert L.} and Pamela DeYoung and Han, {Mei Lan K.} and Wedzicha, {Jadwiga A.} and Nadia Hansel and Zeidler, {Michelle R.} and Wilson, {Kevin C.} and {Safwan Badr}, M. and Atul Malhotra and {Safwan Badr}, M. and Pamela Deyoung and Han, {Meilan K.} and Hansel, {Nadia N.} and Owens, {Robert L.} and Hartmut Schneider and Schwartz, {Alan R} and Wedzicha, {Jadwiga A.} and Wilson, {Kevin C.} and Zeidler, {Michelle R.}",
year = "2018",
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doi = "10.1164/rccm.201712-2510ST",
language = "English (US)",
volume = "197",
pages = "289--299",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "3",

}

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T1 - Research priorities in pathophysiology for sleep-disordered breathing in patients with chronic obstructive pulmonary disease

T2 - An Official American Thoracic Society Research Statement

AU - ATS Assembly on Sleep and Respiratory Neurobiology

AU - Malhotra, Atul

AU - Schwartz, Alan R.

AU - Schneider, Hartmut

AU - Owens, Robert L.

AU - DeYoung, Pamela

AU - Han, Mei Lan K.

AU - Wedzicha, Jadwiga A.

AU - Hansel, Nadia

AU - Zeidler, Michelle R.

AU - Wilson, Kevin C.

AU - Safwan Badr, M.

AU - Malhotra, Atul

AU - Safwan Badr, M.

AU - Deyoung, Pamela

AU - Han, Meilan K.

AU - Hansel, Nadia N.

AU - Owens, Robert L.

AU - Schneider, Hartmut

AU - Schwartz, Alan R

AU - Wedzicha, Jadwiga A.

AU - Wilson, Kevin C.

AU - Zeidler, Michelle R.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Background: Obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) are common conditions; the co-occurrence of these diseases, called the overlap syndrome (OVS), has been associated with poor health outcomes. Purpose: The purpose of this Official American Thoracic Society Research Statement is to describe pathophysiology, epidemiology, outcomes, diagnostic metrics, and treatment of OVS, as well as to identify important gaps in knowledge and make recommendations for future research. Methods: Clinicians and researchers with expertise in sleep medicine, pulmonary medicine, or both were invited to participate. Topics were divided among the participants according to their interest and expertise. A literature search was conducted; the search was not a formal systematic review. Evidence was considered and supplemented with the panelists' nonsystematic clinical observations. Important knowledge gaps were identified. Results: Recommendations for research to fill existing knowledge gaps were made. The recommendations were formulated by discussion and consensus. Conclusions: Many important questions about OVS exist. This American Thoracic Society Research Statement highlights the types of research that leading clinicians and researchers believe will have the greatest impact on better understanding the spectrum of disease, improving diagnosis, and optimizing therapy.

AB - Background: Obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) are common conditions; the co-occurrence of these diseases, called the overlap syndrome (OVS), has been associated with poor health outcomes. Purpose: The purpose of this Official American Thoracic Society Research Statement is to describe pathophysiology, epidemiology, outcomes, diagnostic metrics, and treatment of OVS, as well as to identify important gaps in knowledge and make recommendations for future research. Methods: Clinicians and researchers with expertise in sleep medicine, pulmonary medicine, or both were invited to participate. Topics were divided among the participants according to their interest and expertise. A literature search was conducted; the search was not a formal systematic review. Evidence was considered and supplemented with the panelists' nonsystematic clinical observations. Important knowledge gaps were identified. Results: Recommendations for research to fill existing knowledge gaps were made. The recommendations were formulated by discussion and consensus. Conclusions: Many important questions about OVS exist. This American Thoracic Society Research Statement highlights the types of research that leading clinicians and researchers believe will have the greatest impact on better understanding the spectrum of disease, improving diagnosis, and optimizing therapy.

KW - Apnea

KW - COPD

KW - Hypoxia

KW - Lung

KW - Sleep

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U2 - 10.1164/rccm.201712-2510ST

DO - 10.1164/rccm.201712-2510ST

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VL - 197

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JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

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