Research into a functional cure for HIV in neonates: The need for ethical foresight

Seema K. Shah, Deborah Persaud, David S. Wendler, Holly Taylor, Hannah Gay, Mariana Kruger, Christine Grady

Research output: Contribution to journalArticle

Abstract

In 2013, researchers announced that a newborn child from Mississippi, USA might have been functionally cured of HIV by being given combination antiretroviral therapy within hours of birth. Public and media attention has since been captured by the possibility of finding a cure for HIV transmitted from mother to child. Research into the strategy used for the Mississippi patient is crucially important to establish whether it can be replicated and shown to work in diverse populations. At the same time, any ethical issues likely to arise in such studies should be addressed and not ignored in the pursuit of a functional cure. In this Personal View we identify ethical issues that could arise in research towards achievment of a functional cure for HIV in neonates, including difficult trade-offs associated with choosing the study population and questions about the broader social implications of the research, and propose ways to resolve them.

Original languageEnglish (US)
Pages (from-to)893-898
Number of pages6
JournalLancet Infectious Diseases
Volume14
Issue number9
DOIs
StatePublished - 2014

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Mississippi
HIV
Newborn Infant
Ethics
Research
Population
Mothers
Research Personnel
Parturition
Therapeutics

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Research into a functional cure for HIV in neonates : The need for ethical foresight. / Shah, Seema K.; Persaud, Deborah; Wendler, David S.; Taylor, Holly; Gay, Hannah; Kruger, Mariana; Grady, Christine.

In: Lancet Infectious Diseases, Vol. 14, No. 9, 2014, p. 893-898.

Research output: Contribution to journalArticle

Shah, Seema K. ; Persaud, Deborah ; Wendler, David S. ; Taylor, Holly ; Gay, Hannah ; Kruger, Mariana ; Grady, Christine. / Research into a functional cure for HIV in neonates : The need for ethical foresight. In: Lancet Infectious Diseases. 2014 ; Vol. 14, No. 9. pp. 893-898.
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