Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects

Simona Volpi, Carol J. Bult, Rex L. Chisholm, Patricia A. Deverka, Geoffrey S. Ginsburg, Howard J. Jacob, Melpomeni Kasapi, Howard L. McLeod, Dan M. Roden, Marc S. Williams, Eric D. Green, Laura Lyman Rodriguez, Samuel Aronson, Larisa H. Cavallari, Joshua C. Denny, Lynn G. Dressler, Julie A. Johnson, Teri E. Klein, J. Steven Leeder, Micheline Piquette-MillerMinoli Perera, Laura J. Rasmussen-Torvik, Heidi L. Rehm, Marylyn D. Ritchie, Todd C. Skaar, Nikhil Wagle, Richard Weinshilboum, Kristin W. Weitzel, Robert Wildin, John Wilson, Teri A. Manolio, Mary V. Relling

Research output: Contribution to journalArticle

Abstract

Response to a drug often differs widely among individual patients. This variability is frequently observed not only with respect to effective responses but also with adverse drug reactions. Matching patients to the drugs that are most likely to be effective and least likely to cause harm is the goal of effective therapeutics. Pharmacogenomics (PGx) holds the promise of precision medicine through elucidating the genetic determinants responsible for pharmacological outcomes and using them to guide drug selection and dosing. Here we survey the US landscape of research programs in PGx implementation, review current advances and clinical applications of PGx, summarize the obstacles that have hindered PGx implementation, and identify the critical knowledge gaps and possible studies needed to help to address them.

Original languageEnglish (US)
Pages (from-to)778-786
Number of pages9
JournalClinical Pharmacology and Therapeutics
Volume103
Issue number5
DOIs
StatePublished - May 1 2018
Externally publishedYes

Fingerprint

Pharmacogenetics
Research
Pharmaceutical Preparations
Precision Medicine
Drug-Related Side Effects and Adverse Reactions
Pharmacology
Direction compound
Therapeutics

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Volpi, S., Bult, C. J., Chisholm, R. L., Deverka, P. A., Ginsburg, G. S., Jacob, H. J., ... Relling, M. V. (2018). Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects. Clinical Pharmacology and Therapeutics, 103(5), 778-786. https://doi.org/10.1002/cpt.1048

Research Directions in the Clinical Implementation of Pharmacogenomics : An Overview of US Programs and Projects. / Volpi, Simona; Bult, Carol J.; Chisholm, Rex L.; Deverka, Patricia A.; Ginsburg, Geoffrey S.; Jacob, Howard J.; Kasapi, Melpomeni; McLeod, Howard L.; Roden, Dan M.; Williams, Marc S.; Green, Eric D.; Rodriguez, Laura Lyman; Aronson, Samuel; Cavallari, Larisa H.; Denny, Joshua C.; Dressler, Lynn G.; Johnson, Julie A.; Klein, Teri E.; Leeder, J. Steven; Piquette-Miller, Micheline; Perera, Minoli; Rasmussen-Torvik, Laura J.; Rehm, Heidi L.; Ritchie, Marylyn D.; Skaar, Todd C.; Wagle, Nikhil; Weinshilboum, Richard; Weitzel, Kristin W.; Wildin, Robert; Wilson, John; Manolio, Teri A.; Relling, Mary V.

In: Clinical Pharmacology and Therapeutics, Vol. 103, No. 5, 01.05.2018, p. 778-786.

Research output: Contribution to journalArticle

Volpi, S, Bult, CJ, Chisholm, RL, Deverka, PA, Ginsburg, GS, Jacob, HJ, Kasapi, M, McLeod, HL, Roden, DM, Williams, MS, Green, ED, Rodriguez, LL, Aronson, S, Cavallari, LH, Denny, JC, Dressler, LG, Johnson, JA, Klein, TE, Leeder, JS, Piquette-Miller, M, Perera, M, Rasmussen-Torvik, LJ, Rehm, HL, Ritchie, MD, Skaar, TC, Wagle, N, Weinshilboum, R, Weitzel, KW, Wildin, R, Wilson, J, Manolio, TA & Relling, MV 2018, 'Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects', Clinical Pharmacology and Therapeutics, vol. 103, no. 5, pp. 778-786. https://doi.org/10.1002/cpt.1048
Volpi, Simona ; Bult, Carol J. ; Chisholm, Rex L. ; Deverka, Patricia A. ; Ginsburg, Geoffrey S. ; Jacob, Howard J. ; Kasapi, Melpomeni ; McLeod, Howard L. ; Roden, Dan M. ; Williams, Marc S. ; Green, Eric D. ; Rodriguez, Laura Lyman ; Aronson, Samuel ; Cavallari, Larisa H. ; Denny, Joshua C. ; Dressler, Lynn G. ; Johnson, Julie A. ; Klein, Teri E. ; Leeder, J. Steven ; Piquette-Miller, Micheline ; Perera, Minoli ; Rasmussen-Torvik, Laura J. ; Rehm, Heidi L. ; Ritchie, Marylyn D. ; Skaar, Todd C. ; Wagle, Nikhil ; Weinshilboum, Richard ; Weitzel, Kristin W. ; Wildin, Robert ; Wilson, John ; Manolio, Teri A. ; Relling, Mary V. / Research Directions in the Clinical Implementation of Pharmacogenomics : An Overview of US Programs and Projects. In: Clinical Pharmacology and Therapeutics. 2018 ; Vol. 103, No. 5. pp. 778-786.
@article{7ee45e3929a34553a33b27061d866eb8,
title = "Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects",
abstract = "Response to a drug often differs widely among individual patients. This variability is frequently observed not only with respect to effective responses but also with adverse drug reactions. Matching patients to the drugs that are most likely to be effective and least likely to cause harm is the goal of effective therapeutics. Pharmacogenomics (PGx) holds the promise of precision medicine through elucidating the genetic determinants responsible for pharmacological outcomes and using them to guide drug selection and dosing. Here we survey the US landscape of research programs in PGx implementation, review current advances and clinical applications of PGx, summarize the obstacles that have hindered PGx implementation, and identify the critical knowledge gaps and possible studies needed to help to address them.",
author = "Simona Volpi and Bult, {Carol J.} and Chisholm, {Rex L.} and Deverka, {Patricia A.} and Ginsburg, {Geoffrey S.} and Jacob, {Howard J.} and Melpomeni Kasapi and McLeod, {Howard L.} and Roden, {Dan M.} and Williams, {Marc S.} and Green, {Eric D.} and Rodriguez, {Laura Lyman} and Samuel Aronson and Cavallari, {Larisa H.} and Denny, {Joshua C.} and Dressler, {Lynn G.} and Johnson, {Julie A.} and Klein, {Teri E.} and Leeder, {J. Steven} and Micheline Piquette-Miller and Minoli Perera and Rasmussen-Torvik, {Laura J.} and Rehm, {Heidi L.} and Ritchie, {Marylyn D.} and Skaar, {Todd C.} and Nikhil Wagle and Richard Weinshilboum and Weitzel, {Kristin W.} and Robert Wildin and John Wilson and Manolio, {Teri A.} and Relling, {Mary V.}",
year = "2018",
month = "5",
day = "1",
doi = "10.1002/cpt.1048",
language = "English (US)",
volume = "103",
pages = "778--786",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Research Directions in the Clinical Implementation of Pharmacogenomics

T2 - An Overview of US Programs and Projects

AU - Volpi, Simona

AU - Bult, Carol J.

AU - Chisholm, Rex L.

AU - Deverka, Patricia A.

AU - Ginsburg, Geoffrey S.

AU - Jacob, Howard J.

AU - Kasapi, Melpomeni

AU - McLeod, Howard L.

AU - Roden, Dan M.

AU - Williams, Marc S.

AU - Green, Eric D.

AU - Rodriguez, Laura Lyman

AU - Aronson, Samuel

AU - Cavallari, Larisa H.

AU - Denny, Joshua C.

AU - Dressler, Lynn G.

AU - Johnson, Julie A.

AU - Klein, Teri E.

AU - Leeder, J. Steven

AU - Piquette-Miller, Micheline

AU - Perera, Minoli

AU - Rasmussen-Torvik, Laura J.

AU - Rehm, Heidi L.

AU - Ritchie, Marylyn D.

AU - Skaar, Todd C.

AU - Wagle, Nikhil

AU - Weinshilboum, Richard

AU - Weitzel, Kristin W.

AU - Wildin, Robert

AU - Wilson, John

AU - Manolio, Teri A.

AU - Relling, Mary V.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Response to a drug often differs widely among individual patients. This variability is frequently observed not only with respect to effective responses but also with adverse drug reactions. Matching patients to the drugs that are most likely to be effective and least likely to cause harm is the goal of effective therapeutics. Pharmacogenomics (PGx) holds the promise of precision medicine through elucidating the genetic determinants responsible for pharmacological outcomes and using them to guide drug selection and dosing. Here we survey the US landscape of research programs in PGx implementation, review current advances and clinical applications of PGx, summarize the obstacles that have hindered PGx implementation, and identify the critical knowledge gaps and possible studies needed to help to address them.

AB - Response to a drug often differs widely among individual patients. This variability is frequently observed not only with respect to effective responses but also with adverse drug reactions. Matching patients to the drugs that are most likely to be effective and least likely to cause harm is the goal of effective therapeutics. Pharmacogenomics (PGx) holds the promise of precision medicine through elucidating the genetic determinants responsible for pharmacological outcomes and using them to guide drug selection and dosing. Here we survey the US landscape of research programs in PGx implementation, review current advances and clinical applications of PGx, summarize the obstacles that have hindered PGx implementation, and identify the critical knowledge gaps and possible studies needed to help to address them.

UR - http://www.scopus.com/inward/record.url?scp=85044524491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044524491&partnerID=8YFLogxK

U2 - 10.1002/cpt.1048

DO - 10.1002/cpt.1048

M3 - Article

C2 - 29460415

AN - SCOPUS:85044524491

VL - 103

SP - 778

EP - 786

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 5

ER -