Repurposing developmental mechanisms in the adult nervous system

John L. Hunyara, Alex L. Kolodkin

Research output: Contribution to journalReview article

Abstract

Molecules and cellular processes important for nervous system development can be repurposed in adulthood for the regulation of adult neurogenesis, synaptic plasticity, and neural regeneration following injury or degeneration. Efforts to recapitulate neural development in order to ameliorate injury or disease are promising, but these often fall short of functional restoration due in part to our incomplete understanding of how these damaged circuits initially developed. Despite these limitations, such strategies provide hope that harnessing developmental mechanisms can restore nervous system functions following damage or disease.

Original languageEnglish (US)
Pages (from-to)14-21
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume65
DOIs
StatePublished - Dec 2020

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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