Repurposing clinical agents for chemical exchange saturation transfer magnetic resonance imaging: Current status and future perspectives

Zelong Chen, Zheng Han, Guanshu Liu

Research output: Contribution to journalReview articlepeer-review

Abstract

Molecular imaging is becoming an indispensable tool to pursue precision medicine. How-ever, quickly translating newly developed magnetic resonance imaging (MRI) agents into clinical use remains a formidable challenge. Recently, Chemical Exchange Saturation Transfer (CEST) MRI is emerging as an attractive approach with the capability of directly using low concentration, exchangeable protons-containing agents for generating quantitative MRI contrast. The ability to utilize diamagnetic compounds has been extensively exploited to detect many clinical compounds, such as FDA approved drugs, X-ray/CT contrast agents, nutrients, supplements, and biopolymers. The ability to directly off-label use clinical compounds permits CEST MRI to be rapidly translated to clinical settings. In this review, the current status of CEST MRI based on clinically available compounds will be briefly introduced. The advancements and limitations of these studies are reviewed in the context of their pre-clinical or clinical applications. Finally, future directions will be briefly discussed.

Original languageEnglish (US)
Article number11
Pages (from-to)1-23
Number of pages23
JournalPharmaceuticals
Volume14
Issue number1
DOIs
StatePublished - Dec 2021

Keywords

  • Bioorganic
  • CEST
  • Contrast agents
  • Diamagnetic
  • MRI
  • Molecular imaging

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

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